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Biliary cirrhosis (biliary cirrhosis) due to biliary obstruction, cholestasis caused by cirrhosis of the liver, less common, can be divided into two types of secondary and primary. Primary are more rare.
1. Secondary biliary cirrhosis
Etiology: common causes of blocked bile duct system, such as gallstones, cancer (pancreatic cancer, Vater ampulla carcinoma) such as the oppression of extrahepatic bile duct, causing stenosis and occlusion. In patients with multiple children, because of congenital extrahepatic biliary atresia, followed by total bile duct cyst, biliary cirrhosis (biliary cirrhosis) and so on. Totally occluded biliary system can be caused by more than 6 months this type of cirrhosis.
Pathological changes: Early liver volume usually increases, the surface was smooth or finely granular, medium hardness, equivalent to incomplete separation type. Appearance is often the liver or bile stained dark green-brown. Microscope, liver cell cytoplasm of inner pigmentation, degeneration and necrosis of liver cells and therefore, the performance of liver cell volume increases, loose reticular cytoplasm, nuclear disappear, as mesh or feathery necrosis. Cholestatic bile capillary, bile thrombus. Rupture of bile duct necrosis, bile leak out, the formation of "bile lake." Portal area of bile duct dilatation and bile duct hyperplasia, fibrous tissue hyperplasia and lobular alterations and necrosis than after portal cirrhosis of the light. Associated with bile duct infect


ion are shown in the portal area and how the amount of proliferation of the connective tissue infiltration of neutrophils and even micro-abscess formation.
2. Primary biliary cirrhosis
The disease, also known as chronic non-suppurative destructive cholangitis, is rare in China, cause unknown, may be associated with autoimmune reaction. To occur in middle-aged women. Long-term clinical manifestations of obstructive jaundice, liver bile stimulation and because the skin itching and so on. Also often accompanied by hyperlipidemia and skin xanthoma. Bold tube inside and outside the liver had no significant lesions, portal area can occur in the interlobular bile duct epithelial degeneration and necrosis and infiltration of lymphocytes, followed by destruction of small bile ducts and the emergence of the phenomenon of cholestasis, fibrosis, and invasion, separating lobule, the final develop into cirrhosis.
Medical history and symptoms
The disease often associated with other autoimmune diseases such as rheumatoid joint class, Sjogren's syndrome, scleroderma, chronic lymphocytic thyroiditis and other co-exist, more common in middle-aged women, insidious onset, after a slow, early symptoms of mild Patients generally in good condition, no significant loss of appetite and weight declined more than about 10% of patients may have no symptoms. Of unexplained chronic progressive obstructive jaundice patients, especially those associated with steatorrhea, the incentive should learn more about the onset and progression of the situation, whether the existence of other autoimmune diseases, attention and secondary biliary cirrhosis cause jaundice and other liver cirrhosis were identified.
Experience found that the skin, sclera jaundice shows multiple scratches and scaling. Liver, splenomegaly surface is still smooth, no tenderness.Lipids, serum bile acids, conjugated bilirubin, AKP, and GGT enzymes and other micro-duct was significantly increased, transfer of nitrogen enzymes normal or mild to moderate increase. Anti-mitochondrial antibody-positive blood, IgM increased, prothrombin time prolonged. Positive for urinary bilirubin, urine bile per normal or reduced. Imaging ultrasound, ERCP, CT, PTC, etc. to understand whether the extrahepatic bile duct dilatation and obstructive jaundice caused by extrahepatic disease.
Biliary cirrhosis names of diseases: biliary cirrhosis respective areas: the abdomen treatment department: Neikeneike digestive symptoms and signs of hepatobiliary surgery: hepatomegaly, splenomegaly, jaundice, biliary cirrhosis Introduction
Any cause liver, bile duct disease, leading to biliary obstruction, cholestasis, biliary cirrhosis can be developed. Points of primary biliary cirrhosis and secondary biliary cirrhosis. Knowledge biliary cirrhosis biliary cirrhosis etiology: biliary cirrhosis primary biliary cirrhosis points (PrimaryB. symptoms of biliary cirrhosis: diagnosis is based on: middle-aged women, the skin was itching, liver, biliary cirrhosis xanthoma . check: 1. laboratory (1) blood bilirubin to direct bilirubin is . the differential diagnosis of biliary cirrhosis: including obstructive jaundice, If bile duct stones, common bile duct tumors, pancreatic and bile duct to prevent biliary cirrhosis .: mainly caused by the liver, bile duct causes the disease prevention and active treatment of complications of biliary cirrhosis .: hepatic encephalopathy (hepatic coma): The most common cause of death; . biliary cirrhosis on treatment: 1. UDCA ursodeoxycholic acid Heathcote, etc. with a liver bile sclerosis related articles


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