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Time : Food Business Network Section, classification and treatment principles of childhood lead poisoning
U.S. CDC (Center for Disease Control) of the "Guide for childhood lead poisoning," that the blood lead levels greater than or equal to 10ug/dl, whether or not there is a corresponding clinical symptoms, physical disorders and other blood biochemical changes can be diagnosed as lead poisoning, and the children's blood lead level is divided into five levels, to indicate the different load conditions lead
Grade : <10ug/dl. Relatively safe (but with fetal toxicity, easy to miscarriage, premature delivery, intrauterine growth retardation);
Grade :10-19ug / dl. Can affect cognitive ability and nerve conduction velocity, so that children prone to dizziness, irritability, and lax attention, hyperactivity;
Grade :20-44ug / dl. Can cause calcium deficiency, zinc deficiency, iron deficiency, growth retardation, low immunity, motor incoordination, vision and hearing impairment, unresponsive, reduced IQ, anorexia, different food, anemia, abdominal pain, etc.;
Grade :45-69ug / dl. There may be personality changes, irritability, aggressive behavior, learning difficulties, abdominal cramps, high blood pressure, arrhythmia and movement disorders;
grade: 70ug/dl. Can lead to multiple organ damage, lead encephalopathy, paralysis, coma or even death.
Both symptomatic and asymptomatic lead poisoning in children in sub-clinical lead poisoning, the basic pro


cesses are involved in the pathophysiology of the nervous system, blood system, cardiovascular system, urinary system, immune system and endocrine system. The toxic effects of lead on the body is a zero threshold, that any level of lead can cause some body damage. Between the individual susceptibility to toxic effects of lead are very different. No obvious result of lead poisoning in children's lead exposure history, current diagnosis based on:
1, etiology indicators: bones, blood, tissue and urine of lead is exceeded;
2, damage indicators: iron network synthase activity, VD3 live enzyme activity, ZPP, EP, FEP, ALAD enzymes (which ZPP most sensitive and most easily detected, correlation is better);
3, clinical manifestations: If children are non-specific clinical manifestations, after the exclusion of other common diseases, blood lead testing may be considered to diagnose. Experimental treatment is effective removing lead lead poisoning in children is an important basis for diagnosis.
"New England Journal of Medicine," a research report that low levels of lead in children, can cause lifelong problems, such as serious ing, learning disabilities, poor eye-hand coordination, slow growth, and unresponsive. High levels of lead in the body and ADHD, behavior problems and juvenile crime. In of the seriousness of lead pollution and lead damage is irreversible. China Institute of Child Health treatment guidelines in 2000, provides for the treatment of blood lead levels of lead displacement: those who lead level is not zero, all should accept removing lead treatment.
Treatment includes removing lead drug treatment and the use of chelates of removing lead health food / drink non-drug treatment. Chelate treatment of the principles and methods have been standardized, requiring hospitalization for disposal by a physician for severe lead poisoning ( above). Mild and moderate lead poisoning can be driven health food / drink non-drug therapy is indicated. Removing lead health food / beverage is a non-drug treatment for lead damage to pediatric clinical care is an important means of intervention.
Section II, removing lead chelation therapy drugs
Removing lead with chelating drug therapy drug binding by displacement of lead in blood and tissue lead, the lead with a combination of drugs through urine and (or) fecal discharge, to reduce the body lead burden, lead to the body to prevent toxic the role of therapy.
First, chelation therapy drugs drive the significance of lead
Removing lead indication for treatment to have children, drive the body of lead can significantly reduce the load of lead, and to prevent further production of toxic effects of lead. However, whether treatment for removing lead toxicity has been generated effects are reversible, then there are different opinions. Study found that after removing lead with blood lead levels decline, EP and ALAD and other blood biochemistry showed marked improvement immediately. Toxic effects of lead due to decreased activity of vitamin D3, also lead to treatment with the recovery drive. Lead on the inhibitory effect of thyrotropin and growth hormone, blood lead levels also decreased to 40ug/dl below restored. Ruff and so 54 cases of lead poisoning from 13 to 87 months of age children before and after treatment for removing lead intellectual development, and found lead in the drive by CaNa2EDTA 6 months after treatment, children's blood lead levels drop at the same time, children in the bud development scale and Sidan Fu - than on the development scale scores also have picked up every drop of blood lead level of about 0.3 ug / dl, DQ or IQ increased by 1 point. But there are also studies that treatment can lead a drive discharge of total lead body burden of about 2%, and, removing lead from the treatment of brain tissue removed in the end how much lead is also not clear.
Removing lead toxic effects of lead treatment can prevent further development, no objection to this point. Younger children, the greater the significance of removing lead. On the one hand, young children, lead exposure time is short, in the amount of bone lead storage pool is relatively small, which makes each course in the discharge of lead from the body relatively large amount (perhaps 30% of the total lead content, and even more). On the other hand, the developing central nervous system of the brain than the sound development of neurotoxic effects of lead have a big potential for rehabilitation, the development of blood lead decreased with the recovery of damages more likely.
Reduce the lead burden of lead driving role in the treatment there is a premise that the environment of lead has been properly disposed of. Lead treatment during the flooding, the need to ensure that children have been away from s of lead. Not from the of lead exposure in the case of driving under the lead treatment, but will sometimes increase the absorption of lead.
Second, drug treatment for removing lead indication
According to the 1991 U.S. CDC childhood lead poisoning prevention and control guidelines, removing lead indication for treatment is:
1, the children's blood lead levels in 45ug/dl above;
2, the children's blood lead levels in 25-45ug/dl, while removing lead test positive.
The following children's blood lead levels in 25ug/dl not removing lead treatment.
The indications for treatment centers currently adopted by the majority of lead poisoning.
Lead test procedures take into account the complexity of driving, expensive and time-consuming, it was suggested that the blood lead levels in children with lead poisoning 25-45ug/dl, not based on blood lead levels to determine whether treatment for removing lead, but according to the following standards : (1) reflect other toxic effects of lead show marked biochemical changes, such as EP increased, ALAD decreased, etc.; (2) children under 2 years of age; (3) the environment, 2 to 3 months after intervention blood lead level is still continued to rise.
Meet one of the three blood lead levels in children with lead poisoning 25-45ug/dl removing lead should be given treatment.
Third, removing lead drug treatment
Modern medicine for the treatment of lead poisoning is relatively simple, more side effects, clinical application has some limitations, but can not be used for high blood lead level is not sub-clinical lead poisoning and prevention of childhood lead poisoning. No more than two major drugs: EDTA Metal chelating agents to carboxyl (-COOH) and get rid of lead chelation, DMSA class competitive antidote to active thiol (-SH) win combined with the cells and enzymes in the lead to promote the dissociation of lead from the organization and make it be ruled out. EDTA drugs because the role of lead is not specific specific effect, therefore, lead chelation chelation also essential trace elements in vivo in the treatment process, sometimes urinary zinc, copper and lead in urine excretion over the row is also volume over this pathogen harms caused by trace elements in the phenomenon of loss of Heng. Lead is not completely coupled, accumulate in bone tissue and organs under certain conditions can lead to re-enter the blood, showing once again lead toxicity damage.
Removing lead the ideal number of drugs should have the following characteristics: (1) to reduce the lead load target cells; (2) can prevent or improve the function of damage caused by lead toxicity; (3) other elements had no effect on the metabolism of the body; (4) the role of the drug itself is not toxic or toxic effects is very small. Currently, more in line with these conditions, the clinical application of more flooding in several drug lead.
(A) EDTA calcium
Calcium disodium EDTA (calcium disodium edetate, or CaNa2EDTA) is the most common childhood lead poisoning treatment. Drug for the treatment of lead poisoning and other heavy metal poisoning than 50 years.
1, Pharmacology CaNa2EDTA intravenous half-life in blood is 20 to 60 minutes, 1 hour after administration excreted from the urine of 50% of the total dose. Drugs into the human body mainly distributed in the extracellular fluid and cerebrospinal fluid concentration of drug plasma concentrations can reach 5%. Drugs can not enter red blood cells, can easily pass through the placenta, the distribution in the fetus and the mother's body almost. After injection CaNa2EDTA, in concentrations rose, while blood lead and brain will lead a transient rise (this treatment of lead encephalopathy negative). CaNa2EDTA combination of lead and from the renal excretion, urinary lead levels could not drug when compared with an increase of 20 to 50 times. Normal renal function is necessary for drug metabolism.
2, usage and dosage: CaNa2EDT
A must parenteral administration, intravenous injection is the preferred method. Very poor oral absorption effect, not only without any pharmacological effect, but increased absorption of lead. Daily dosage of Ca Na2EDTA 1g/m2, or saline with dextran concentration of 0.5% in preparation of intravenous infusion or several times after the intravenous injection. With 3-5 days for treatment. If, after the end of treatment in a 7 to 14 days, blood lead levels rose to 45ug/dl over again, can be given 2 treatment.
Study found that treatment of childhood lead poisoning alone CaNa2EDTA encephalopathy does not reduce the mortality, this may be related to drug use instead of in brain tissue of an increase in lead levels. For this reason, the current treatment of lead encephalopathy is to use dimercapto propanol, dimercapto-propanol to be play a role, while the kidney and then began to start urinary CaNa2EDTA.
Course of treatment varies, the typical treatment is twice a week, three hours each. In addition to using EDTA, but also often intravenous vitamin C, magnesium and minerals, but according to the individual's condition and laboratory test results may be.
Note: (1) must not be replaced by Na2EDTA CaNa2EDTA, the former in the course of treatment can cause severe hypocalcemia, and even convulsions and death;
(2) patients with renal dysfunction should not use CaNa2EDTA;
(3) should be monitored during treatment of liver and kidney function. Appear in urine formed elements and cellular proteins, blood urea nitrogen, creatinine increased renal involvement suggest, should be discontinued. The first 5 days of treatment, liver transaminase may be increased. However, under normal circumstances, this is a transient, approximately 1 week after treatment is stopped restore to its original level;
(4) CaNa2EDTA lead in the drive, but also discharge other elements, such as zinc, iron, serum zinc during therapy can be reduced by 30% to 40%. Therefore, after treatment in removing lead, should be monitored and added the elements. However, if the lead in the drive to add these elements during the treatment period, will reduce the effect of removing lead drug.
(B) dimercapto propanol
Dimercapto-propanol (Dimercaprol, also known as British anti-gas agent Luis BAL) is 40 years combined antidote. Began reporting in 1947 for the treatment of lead poisoning, confirmed a report in 1950 to significantly reduce the mortality rate of childhood lead poisoning encephalopathy.
1, Pharmacology intramuscular injection of 30 to 60 minutes after the plasma concentration reached a peak two BAL molecules can bind a metal atom to form a stable complex. The formation of complex drugs and lead can be excreted through the stool or urine. Metabolism of drugs by lowering the basic end at 4 hours after. After the secretion of most drugs by the intestinal bile excretion, therefore, in the case of renal dysfunction can also be applied. Drugs have a higher ability to remove bone lead on red blood cell chelation of lead also available. However, renal clearance, brain tissue and the ability to lead in soft tissues inferior to CaNa2EDTA.
2, clinical use and dosage of the preparation is 10% of the oil for deep intramuscular use. BAL is mainly used for symptoms of lead poisoning or lead poisoning in children with encephalopathy, often combined with CaNa2EDTA. Treatment initially 75mg/m2BAL deep intramuscular injection, and then the same dose intramuscular injection once every 4 hours, at a total dose of 450 mg/m2. A course of 3-5 days.
Should be monitored during treatment of liver, kidney function and water and electrolyte balance. At the end of treatment, such as 1 5 to 7 days after the blood lead level has risen to 45ug/dl above can be used alone CaNa2EDTA for the first 2 treatment.
Note: (1) G-6-PD deficiency in children, BAL can cause hemolysis, therefore, only these patients before considering life is in danger of lead poisoning with BAL as removing lead agent.
(2) iron can not be used during treatment. BAL and strong iron binding capacity, and generate complex toxic effects.
(3) 30% to 50% of the children during the BAL treatment of mild fever, liver transaminase elevation, nausea, vomiting, tachycardia, sweating and other adverse reactions, but in most cases these symptoms is a transient in drug metabolism, excretion disappeared.
(C) penicillamine
Penicillamine in 1956 for the treatment of occupational lead poisoning. First used in 1970 cases of childhood lead poisoning. In the United States has not yet been approved by the FDA for the treatment of lead poisoning in children. But some people think, penicillamine of lead poisoning in children under 40ug/dl treatment safe, effective, convenient medications, and adverse reactions are relatively small, there may be more long-term for treatment. Rebound phenomenon of blood lead level of less light.
1, pharmacology, oral absorption, 1 to 2 hours to achieve serum concentrations that peak, half-life of about 1 hour. Penicillamine together to form complexes with lead is excreted from the urine. Penicillamine combined with the specific mechanism of lead still may be: (1) Lead a single atom in the thiol penicillamine combined; (2) Lead with the adjacent sulfur and nitrogen atoms; (3) molecules of two penicillamine a lead atom. Aluminum, magnesium, acid and food can affect drug absorption.
2, usage and dosage penicillamine can be used for blood lead levels in children with lead poisoning 20ug/dl-40ug/dl. Daily dose of 25 ~ 35mg/kg. Start with small doses to reduce adverse reactions. The beginning of a daily dose of 10mg/kg, once orally. 2 weeks to a daily 20mg/kg, orally 2 times. Two weeks before treatment and follow-up treatment of children, repeat the determination of total blood cell count, platelet count, urinalysis, blood urea nitrogen and creatinine. Observation of skin rash and gastrointestinal reactions and other adverse reactions. 3 weeks later the whole amount available. Sachs 1001 cases treated with penicillamine lead poisoning in children. The 20 ~ 25mg/kg per day for 4 weeks of treatment, blood lead levels exceeding the 50ug/dl share from 8.5% before treatment dropped to 3.8%. Shannon and other blood lead level of 75 cases of lead poisoning in children in 25ug/dl-40ug/dl findings is that 76 days of treatment can decrease blood lead level of 33%.
Note: (1) penicillamine removing lead agent is not specific, it is excreted in the Lead at the same time other essential trace elements such as zinc, copper, should be the same time or after treatment in the treatment of timely replenishment.
(2) iron treatment while taking a serious decline in the effectiveness of penicillamine in removing lead.
One of the following circumstances should be immediately discontinued (1) blood lead levels continue to rise (Hint lead exposure is continuing); (2), generalized urticaria; (3) platelet count of 1 million or less; (4) white blood cells count in the 3 thousand less; (5) or proteinuria, hematuria (red blood c 10 / high magnification field), pyuria ( 10 / high magnification field).
(D) dimercaptosuccinic acid
Dimercaptosuccinic acid (2,3-dimercaptosuccinic acid, DMSA) 50 years synthetic drugs for the treatment of schistosomiasis. Ding Guangsheng Chinese pharmacologist in 1965 found that DMSA and other lead poisoning can be the first to achieve the same therapeutic effect with CaNa2EDTA. Since then, DMSA is widely used in the treatment of occupational lead poisoning. January 1991, FDA formally approved as an oral medication used in treatment of removing lead the treatment of lead poisoning in children, became the first officially approved oral drug treatment of childhood lead poisoning. MSA is effective, can selectively Lead, convenient administration, easy for the children and parents to accept the course of treatment without hospitalization, help to reduce health care costs. DMSA application to become the treatment of lead poisoning in children 90 years the most important progress.
1, pharmacology, oral DMSA can not fully absorb the drug absorbed into the bloodstream after 95% and plasma protein binding, plasma concentration peaked at 2 hours, half-life of 48 hours. DMSA can be combined into a water-soluble complexes with lead excretion from the kidney, the specific mechanism is unclear. Animal experiments show that, DMSA's effect of removing lead than CaNa2EDTA, especially for soft tissue and brain and kidney tissue clearance lead a strong ability to lead toxicity on the biochemical changes caused by improved results would be better.
2, usage and usage in the clinical application of MSA is still gradual accumulation of experience. DMSA is generally used in blood lead levels in children with lead poisoning of more than 4 (for children under 1 year of age effects and adverse reactions has not been investigated). 5 days before each dose of 10mg/kg, every 8 hours orally once. 6 days, dose adjustments for each 10mg/kg, orally once every 12 hours. A course of 19 days.
3, clinical studies have shown that, EMSA to dose and blood lead and urine lead down the secretion of dose effect relationships were good. Graziano and other research in 1988 found that daily 30mg/kg of DMSA with lead poisoning reduction of blood lead and reverse the biochemical changes related to best effect. After stopping
2 weeks, CaNa2EDTA group returned to pre-treatment blood lead level of 100% level, and DMSA treated group returned to the level of blood lead level of 60% before treatment. The researchers believe that regular maintenance dose administered 5 days after 2 weeks to help reduce blood lead rebound.
In animal studies, DMSA not only to promote the role of Lead, as well as the role of inhibition of lead absorption. But the second effect not confirmed in clinical studies. Stremski 17 cases of lead poisoning and other children found that children from lead pollution of the environment if you do not, DMSA does not reduce blood lead levels, this description, DMSA does not reduce the absorption of lead.
Results of clinical studies can be summarized as follows:
(1) in the course of the first phase (the first 5 days), daily 30mg/kg dose of DMSA can make blood lead level dropped to 30% before treatment to 40%.
(2) and the other drive as lead drugs, significantly after treatment blood lead levels rebound. However, DMSA reduced blood lead levels rebound after the less. Therefore, to achieve satisfactory results, drug treatment must be more.
(3) DMSA can lead toxicity caused by reversal of the metabolic disorder. ALAD activity and blood lead levels rise in parallel decline.
(4) DMSA may lead drug safety than any other drive. 30mg/kg dose in a daily treatment, DMSA had no significant adverse reactions reported.
Note: (1) medication, you should ensure that the environment from lead pollution; (2) in the treatment process should be monitored weekly complete blood count, liver transaminase levels and blood lead levels; (3) the end of treatment should also be testing week Blood lead level; (4) 4% of the sick child during treatment rash, gastrointestinal discomfort, nausea, vomiting, diarrhea, loss of appetite and other adverse reactions, about 6% to 10% of the sick child would appear abnormal liver transaminases, drug should be discontinued if severe rash; (5) If necessary, DMSA treatment can be repeated multiple courses, but at least two courses separated by 2 weeks.
(E) drug succimer (Chemet)
succimer (Chemet), dimercapto succinic acid, has been FDA approved for chelation of lead in children. The drug can reduce disease and death caused by lead poisoning. Succimer only approved for use in children with high blood lead levels (above 45ug/dl). Pyrrolo quinoline quinone (PQQ), bacteria in a variety of important cofactor of enzymes, can affect the respiratory chain function and free radicals level. Xu Qin and other findings ("863" project), PQQ can reduce the lead content of lead poisoning in mice. PQQ with fewer toxic side effects, does not affect the body content of copper and zinc, lead can be added the lack of damage caused by endogenous PQQ advantages, therefore, have to become the treatment of lead poisoning in children safer drugs.
(F) Chinese medicine treatment
Chinese medicine diagnosis and treatment of disease is unique, in its ideology is based on the overall concept as a guide, both pathogen, treating the symptoms, often through role in the overall adjustment for therapeutic purposes. Lifting of lead poisoning on TCM, Chinese ancient literature Jiuyou detoxification prescription records, modern but no systematic study is mostly seen in reports of symptoms based Tangji symptomatic treatment, such as Dan Shen abdominal blood circulation Huanjie lead cutter pain, Dachengqitang lift pass in the capture of constipation . However, due to very different clinical symptoms of lead poisoning, in addition to evidence of constipation, abdominal cramps of blood stasis, there are Yin Huo-wang, yang, and other disease, which is very symptomatic of the limitations of the use of prescription, there is solution to the problem is that the present will seek medical treatment, failed to lift the lead poisoning, the role of symptomatic treatment to relieve symptoms are only temporary.
Recent studies have shown that some Chinese medicine, right from wrong in the overall of both theoretical guidance, the legislation prescribed to detoxify Quxie based, supplemented by righting the spleen, the initial clinical results good, not only can reduce the body burden of lead , compared with Western medicine has its side effects, Lead selective high (on the other elements little influence the metabolic process) and so on. In the study of occupational disease prevention, more reports for "Tat drink" Chinese Lead drinks (experiments being, not listed.) Chinese "Chen Gong Tomoko" also has educational and promote the role of Lead. The exact effect remains to be further clinical validation.
Fourth, removing lead follow-up after treatment
Treatment by removing lead, blood lead was removing lead from the body with drugs, blood lead levels decline rapidly. General flooding after treatment of lead and blood lead levels were in the 25ug/dl below. However, due to the rapid decline in blood lead, blood lead and bone lead was broken between the original balance, a large number of bone lead will be transferred to the blood pool, in order to achieve a new dynamic equilibrium. This process makes the blood lead levels rise sharply in the short term, sometimes close to the original level. The rebound phenomenon of blood lead level is common in clinical practice, particularly with chronic lead exposure in children, longer periods of time, often after removing lead - lead the rebound - and then removing lead - and then bounce - and then removing lead - then bounce repeatedly and many other courses of treatment, can lead to bone tissue gradually removed.
To understand the rebound of blood lead after treatment the situation should be the end of treatment 7 to 21 days after the lead again measured to determine whether it is necessary once again to the next course of treatment. In principle, driving with a BAL or CaNa2EDTA lead in children, lead in the drive after the end of treatment, every patient should be followed up for 4 to 6 weeks, then once a month outpatient follow-up, a total of 12 months. Children treated with DMSA, can be followed up once every other week a total of 3 to 4 times (6 to 8 weeks), and then once a month, a total of 4 to 6 times. Follow-up included: blood lead measurement, lead poisoning, the symptoms and signs, as well as improvements in environmental conditions and so on.
Section III, to promote excretion of functional food
Proper nutrition measures can improve the body's resistance of the system to enhance the metabolic detoxification of toxic substances and reduce absorption of toxic substances and to promote the conversion of non-toxic substances from the body, is conducive to recovery. Must be noted that people with the poison of lead pollution in the period after the disengagement, the former lead into the body will continue to occur in vivo accumulation of toxic effects, or body organ damage due to lead have not yet returned to normal. Therefore still need to give the necessary for the toxic nature of the health measures.
The current prevalence of childhood lead poisoning problem, mostly mild or moderate chronic accumulation of poisoning, clinical manifestations to live is not obvious. Due to maternal and child in a special physiological stage, the body needs the nutrients and the degree of sensitivity than the higher toxic, safe detoxification, proper nutrition has become the most important means of prevention.
In fact, the use of nutrients to promote excretion and anti-lead half a century ago is the people know, the calcium phosphate-based nutritional supplements and vitamins such as the years have come out to lead workers to provide health care. Until 20 years ago, one from amino acids, vitamins and mineral composition of the compound preparation - "Lead-X" - on the market, non-drug prevention and treatment of childhood lead poisoning before entering a new world of ease.
China has still a lack of childhood lead poisoning prevention and treatment specifically for the nutritional health products. July 2000, will be lead by the Chinese policy research commissioned by the Study Group on Prevention, Nutrition Society of China experts of our children's diet based on characteristics of compound preparation, "Qing Qian brand strength Technip" (Lead-X) is improved and R & D, West China Medical University, Gansu Academy of Medical Sciences, Lanzhou Medical College, and several domestic hospitals and the promotion of its security function of a large number of Excretion experiments prove that "force Technip Qing Qian card" is a nontoxic food with lead to prevent lead absorption and promote excretion of health functions, for taking a month can significantly reduce the body's blood, liver and bone lead levels, increases the urinary excretion of lead, without affecting the excretion of calcium and zinc. "Qing Qian brand power Technip" to calcium and vitamin C as the main ingredient, by the Harvard School of Public Health Yawen Chen, Professor, Center for Disease Control and Professor Carol Balleu Xinhua Hospital, Shanghai Second Medical University, Professor Shen Xiaoming, a strong research support. Organized by the Ministry of Health expert reand certification of health food, at present, has been on the market, she brought our children safe and reliable lead poisoning prevention and control of the weapon.
Excretion of the compound to promote - "Qing Qian brand power Technip"
"Qing Qian force Technip card" is the prevention and control experts in recent years many efforts lead crystal. It fully into account our children, maternal nutritional and dietary structure and characteristics of scientific formula, carefully produced by a wide range of national clinical studies have shown that long-term use can be effective in promoting Paiqian, significantly reduced the blood, bones and other dirty control the content of lead, without affecting the calcium, zinc and iron metabolism of nutrients and balance, therefore, is to carry out children and pregnant women in China lead poisoning lead the work of non-drug drive, zero-lead works best choice.1, reasonable than the competitive inhibition of calcium and phosphorus in the gastrointestinal tract of lead absorption and transport, and promote lead excretion;
2, the high affinity of seabuckthorn (wild fruit) and pectin polysaccharides form a gel can be combined with lead, promoting excretion of lead from the feces.
Two promote dissociation and excretion of lead
1, a variety of trace elements in living tissue can activate enzymes, to promote the dissociation of lead from the organization;
2, hydrolyzed protein rich in-SH active genes, can lead from the replacement of the organization to promote lead excretion;
3, a large number of acid to form soluble complexes with lead compounds excreted through urine.
Three against damage, promote repair
1, is rich in bioflavonoids and vitamin C, etc., contribute and lead in the effects of antagonism of lead induced oxidative and free radical damage;
2, the liberation of lead in the closed channels, receptors and live enzymes, metabolism and function return to normal activities;
3, supplement the body required amino acids, minerals, trace elements and vitamins to promote growth and development.
Huaxi Medical University School of Public Health of the "brand power of the Qing Qian Technip" Lead features for total evaluation of the experiment: "force Technip" no adverse effect on the body weight of mice, the mice on the high lead exposure can promote the Lead effect. Can significantly reduce blood lead levels in mice, liver and femur lead content of lead content. Daily doses of human subjects, "Qing Qian brand power Technip" 4-6 tablets, and even served 30 days, the human blood lead levels were significantly reduced. "Qing Qian force Technip card" on the lead in urine, urinary calcium, urinary zinc affect the dynamic study also showed that subjects taking the "brand power of the Qing Qian Technip" after significant increase in urinary excretion of lead, zinc and calcium and urine no significant difference in excretion. That "force Technip" Lead role in the promotion of the human body has, without affecting the excretion of calcium and zinc. Toxicology testing showed that the "brand strength Dexi Wei Qing Qian chewable fruit powder sugar" no obvious toxicity.
"Brand power Dexi Wei Qing Qian chewable fruit powder sugar" is approved by the Ministry of Health has the "promotion of Lead," the efficacy of health care products, for milk-based fruit shaped chewable tablets for children, pregnant women and lead pollution in with the crowd. Usage: 1.2 g / piece, 2-3 / time, 2 times / day, Juefu or sublingual.


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