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How to define Western lactic acidosis
panjk.com Popularity Index: 0 Time : Keywords: Western Introduction to the definition of lactic acidosis
Newsletter: lactic acid as an intermediate product of sugar metabolism. When the grape stage of glycolysis to pyruvate oxidation is not easy when lacking O2 into lactic acid can lead to lactic acidosis (lactic acidosis). Normal blood lactate was 0.5-1.2mmol / L, about 10 times that of pyruvate. When the blood concentration increased up to 5mmol / L or more can occur when the lactic acidosis. Sometimes up to 30mmol / L or more, the diagnostic criteria for the 7mmol / L .
Lactic acid as


an intermediate product of sugar metabolism. When the grape stage of glycolysis to pyruvate oxidation is not easy when lacking O2 into lactic acid can lead to lactic acidosis (lactic acidosis). Normal blood lactate was 0.5-1.2mmol / L, about 10 times that of pyruvate. When the blood concentration increased up to 5mmol / L or more can occur when the lactic acidosis. Sometimes up to 30mmol / L or more, the diagnostic criteria for the 7mmol / L.
What is old diabetic lactic acidosis Qianlong
What is old diabetic lactic acidosis, which is how it happened, and how to prevent, diabetes experts to answer them one by one to us.
Various causes elevated levels of blood lactate acidosis as a result of lactic acidosis. Based on the occurrence of diabetic lactic acidosis is called diabetic lactic acidosis.
First, the disease causes:
1. Because poorly controlled diabetes diet therapy, exercise therapy and drug treatment shall not be treated, poorly controlled diabetes, patients may have elevated blood sugar, dehydration and oxidation of pyruvate and lactate metabolism disorder defects, resulting in elevated blood lactate.
2. Other diabetic complications such as acute infections, ketoacidosis and hyperosmolar nonketotic coma and other acute complications of diabetes, also known as lactic acidosis in diabetic incentive.
3. Other important organs of diseases such as cerebrovascular accident, myocardial infarction, respiratory diseases and other tissues and organs can cause or aggravate poor blood perfusion, resulting in hypoxemia and lactic acidosis.
4. Biguanide phenformin taking a large number of drugs, especially phenformin (phenformin) increased anaerobic glycolysis, inhibition of the liver and muscles of lactic acid uptake, inhibition of gluconeogenesis, it has caused the role of lactic acidosis, In the case of poor choices, such as senior citizens, with cardiopulmonary disease, diabetes, liver and kidney in patients with large doses of phenformin (phenformin), there are induced lactic acidosis possible.
5. Others such as alcohol, carbon monoxide poisoning, salicylic acid, catecholamines, even when excess lactose also induced lactic acidosis.
Second, due to lactic acidosis there is no satisfactory method of rescue, the mortality rate of 50% or more. Therefore, to prevent its occurrence is very important. Prevention methods are:
1. When impaired renal function, increased blood lactate accumulation is easy, therefore, who have renal dysfunction, should not be used biguanide hypoglycemic agents. These drugs have increased the role of lactic acid.
2. There is shock, heart failure, respiratory failure, hypoxia, etc., should be controlled as soon as possible.
3. Including impaired liver and kidney function, should avoid the use of the drug increased blood lactic acid, such as the biguanide hypoglycemic agents, ethanol, methanol, xylitol, salicylates, isoniazid, dopamine.
5. To avoid the use of ethanol, methanol, xylitol, salicylates, isoniazid and other drugs.
6. As far as possible without fructose, sorbitol and the use of glucose, in order to avoid the disease.News Hotline: 13901115636


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