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Abstract: Congenital diaphragmatic hernia (congenital diaphragmatic hernia, CDH) is due to congenital diaphragmatic defects caused by dysplasia, occurs in the left side of the role of environmental factors may be caused in susceptible individuals a congenital disease. Molecular basis of congenital diaphragmatic hernia and genetic factors is unknown. According to reports in the incidence rate of 1:2500 births, although children born in the positive after treatment and surgical repair defects, the survival rate is still low. Now that its merger pulmonary hypoplasia and pulmonary hypertension is a major cause of death. Studies have shown that lung hypoplasia and CDH-inch may be occurring the same day, diaphragmatic closure may need to ridicule the normal development of the lung. Therefore it was hypothesized that pulmonary hypoplasia is the result of interference embryos, number of pages: 3 pages :102-104 page range Key words: lung hypoplasia in children with congenital diaphragmatic hernia in the molecular biology of pulmonary hypertension in congenital dysplasia and easy genetic factors of individual environmental factors being subject classification: R726.2 [medicine, HEALTH "Pediat pediatric surgery SCIENCES" pediatric plastic surgery] R726.556 [medicine, HEALTH "Pediat pediatric surgery SCIENCES" Pediatric Surgery of the physiological systems ] Related Articles: Topics related references (35) citations (6) coupling the literature (12)
Congenital diaphragmatic hernia


in English called cOngenital diaphragmatic hernia, congenital diaphragmatic defects as part of diaphragm abdominal viscera into the chest through the defect to form a diaphragmatic hernia.
I. The main clinical manifestations of congenital diaphragmatic hernia
1. Respiratory distress, cyanosis, and even recurrent respiratory infections.
2. Industry shift to the opposite side heart, palpitations, circulatory disorder.
3. Anemia, chest pain, abdominal pain, vomiting.
4. Complete or partial obstruction.
5. Ipsilateral thoracic percussion drum sounds, breath sounds decreased or disappeared, the chest Ming bowel sounds can be heard.
Second, the diagnostic criteria of congenital diaphragmatic hernia
1. Neonatal respiratory difficulties, cyanosis.
2, heart sector shift to the opposite side.
3. Anemia, chest pain, abdominal pain, vomiting.
4. Ipsilateral thoracic percussion drum sounds, bowel sounds can be heard chest.
5. See before and after the X ray film and B-ultrasound.
Third, the experimental congenital diaphragmatic hernia examination
1. X ray before and after the film, showing mediastinal shift, chest of intestinal loops filled with gas.
2. B ultrasonic examination, the lesion corresponding parts of the intestine diaphragmatic hernia were seen in organs sonogram.
Fourth, the differential diagnosis of congenital diaphragmatic hernia
1. Other space-occupying abnormalities, X-ray examination can identify.
2; congenital lung cyst and pulmonary infection, diaphragmatic hernia was boat-shaped abdomen, abdominal little gas.
3. Staphylococcal pneumonia, X-ray examination can identify.
Fifth, the treatment of congenital diaphragmatic hernia
1. Home immediately after diagnosis, treatment of neonatal head-chest position.
2. Surgery.
VI Prenatal diagnosis of congenital diaphragmatic hernia
1. Method B-ultrasound.
2. The results determine the prevalence of fetal displayed:
(1) abnormal ultrasound echoes with the peritoneal cavity, the analysis in order to make the diagnosis.
(2) mediastinal shift, cardiac displacement.
(3) intrathoracic stomach bubble can be displayed, intestinal hypoechoic areas, polyhydramnios.
1. The incidence of live births in group O. 5%. A O. 2% o.
2. Age can be found after birth.
3. Polygenic mode of inheritance.
4. Pedigree analysis is more simple and more genetic diaphragmatic hernia, which is characterized by the general population prevalence for the O. 1%. ~ 1. O%. , A relative prevalence of 1. O% a 10, O%, relative prevalence diminishes with distant relatives, a relative prevalence of the square root of population prevalence. Parent, compatriots in more patients, the greater the risk of recurrence. Note syndrome.
5. Women with recurrence risk estimates of 7.2% recurrence risk compatriots, compatriots in male patients the risk of recurrence of 2.6%, 6.7% recurrence risk children.
6. Medical advice
(1) light, surgical treatment, the effect is good, heavy patients early after birth and death.
(2) has given birth to a couple of children, recycled children, can be prenatal diagnosis, fetal illness, continued pregnancy, but must tell the families of the situation, whether to continue pregnancy, the decision by the families of the parties.
(3) light were non-disabling genetic disease, can be treated; not affect marriage and childbearing.
(4) If associated with other syndromes, according to the syndrome case.


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