Health Worlds

Anti-allergy drugs of Chapter
1, anti-allergy drug classification, type of structure, mechanism and structure-activity relationship
2, histamine H1 receptor antagonist: diphenhydramine hydrochloride, chlorpheniramine maleate, cyproheptadine hydrochloride chemical name, chemical structure, physical and chemical properties and uses
3, histamine H1 receptor antagonist: Cetirizine hydrochloride, loratadine, to loratadine, ketotifen fumarate, terfenadine, midazolam Division NOAA, the chemical structure of mizolastine and use
4, the allergic reaction media release agent resistance: cromolyn sodium, SECRETARY your special song, pranlukast and use of the chemical structure1, adrenal cortex hormones drugs classification, type of structure, mechanism and structure-activity relationship
2, glucocorticoid drugs: hydrocortisone acetate, dexamethasone acetate, the chemical name, chemical structure, physical and chemical properties and uses
3, glucocorticoid drugs: prednisolone acetate, fluocinolone, triamcinolone acetonide and use of the chemical structure
Sex hormones and contraceptives, the thirty-second chapter
1, the classification of sex hormones and contraceptives, type of structure, mechanism, structure-activity relationship and metabolic characteristics
2, male hormone drugs: A testosterone, testosterone propionate, Nandrolone phenylpropionate chemical name, chemical structure, physicochemical properties and uses; danazol, finasteride and use of the c


hemical structure
3, the female hormone drugs: estradiol, ethinyl estradiol the chemical name, chemical structure, physicochemical properties and uses; diethylstilbestrol, clomiphene, raloxifene and use of the chemical structure
4, progesterone drugs: progesterone, medroxyprogesterone acetate, norethindrone, levonorgestrel chemical name, chemical structure, physicochemical properties and uses; megestrol acetate, the chemical structure of mifepristone and use
Diphenhydramine: This product is a derivative of ethanolamine may be released from the tissue cells on the competitive effects of histamine H1 receptors, thereby preventing the onset of anaphylaxis, histamine-induced spasm and relieve congestion and so on.
Gentamicin: This is the mechanism of bacterial 30S ribosomal subunit, inhibiting bacterial protein synthesis. In recent years, gram-negative bacilli to gentamicin resistant strains have increased significantly.
SD: This product is in the sulfadoxine, enzyme production of non-Staphylococcus aureus, Streptococcus pyogenes, Streptococcus pneumoniae, Escherichia coli, Klebsiella, Salmonella, Shigella and other Enterobacteriaceae bacteria, Neisseria gonorrhoeae, meningococcal, Haemophilus influenzae has an antibacterial effect, in addition to C. trachomatis in vitro, star slave card bacteria, parasites and Toxoplasma gondii have anti-microbial activity. Antibacterial activity of this product with yl sulfamethoxazole. But in recent years, bacterial resistance to the chemicals increased, especially Streptococcus, Neisseria, and Enterobacteriaceae. Broad-spectrum antibacterial agent for the sulfonamides. This product is similar in structure to the amino acid (PABA), PABA can be competitive with the role of bacteria in the body in the dihydrofolate synthase, thereby preventing the synthesis of PABA as a raw material required for folic acid bacteria, reducing the metabolic activity of THC with the amount of folic acid, while the latter is the bacterial synthesis of purine, thymidine, and deoxyribonucleic acid (DNA) of the required material, thus inhibiting bacterial growth and reproduction.
Trimethoprim: Trimethoprim (TMP) is a bacteriostatic agent, for the lipophilic weak base, is the chemical structure of pyrimethamine class. Its Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Salmonella, Shigella have antibacterial activity against Streptococcus pneumoniae, Neisseria gonorrhoeae, Neisseria meningitidis bacteria was not obvious , had no effect on P. aeruginosa. This product is the mechanism of folic acid to interfere with bacterial metabolism. Selective inhibition of bacteria mainly dihydrofolate reductase activity, so that dihydrofolate does not reduce to tetrahydrofolate, and synthesis of nucleic acid biosynthesis of folic acid is the major component, so the product prevents the synthesis of nucleic acids and proteins of bacteria, and the goods and bacteria than the combination of dihydrofolate reductase enzyme with the mammalian 5 million to 6 million times closer. The goods and sulfa drug combination of folic acid synthesis and metabolism of bacteria could have been a double block, a synergistic effect, the antibacterial activity of sulfa drugs increased, and sterilization can become inhibitory effect, reduce the resistant strains.
Salbutamol: The selective 2 receptor agonists can selectively excited the 2 receptor of bronchial smooth muscle, there is a strong bronchodilator effect. In asthma, the bronchodilator effect of isoproterenol at least equal. Inhibition of mast cells and other cells to release allergic sensitization of bronchial smooth muscle spasm and its media are also related to the role. 1 receptors on the heart of the exciting role of weak, so the effect of increasing heart rate and isoproterenol is only 1 / 10. Selective 2 receptor on bronchial smooth muscle excitement, relaxation of bronchial smooth muscle, relieve bronchospasm, bronchodilator effect of strong, weak heart 1 receptor is more secure, the most commonly used asthma drugs.


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