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Lactic acidosis induced diabetes causes what? Practical Diabetes
Lactic acidosis induced by DM common reasons are as follows.
poor glycemic control.
other acute complications of diabetes, such as infection, ketoacidosis and hyperosmolar nonketotic coma and other acute complications, often because of shock, tissue hypoxia, competitive inhibition of keto acid oxidation induced by factors such as diabetes, lactic acidosis poisoning.
combined with other important organs of the disease, such as cerebral vascular accident, myocardial infarction, respiratory diseases, chronic diseases such as liver and kidney dysfunction, may cause or aggravate poor blood perfusion of tissues and organs, leading to hypoxemia and lactic acidosis.
biguanide drugs misuse, biguanide drugs, especially phenformin (phenformin) due to increased anaerobic glycolysis, inhibition of liver and muscle lactate uptake and inhibition of gluconeogenesis caused lactic acidosis. Determined to diabetic patients, such as combined liver and kidney disease, but also taking a large number of phenformin, there are induced lactic acidosis possible.
others such as alcohol, carbon monoxide poisoning, salicylic acid, catecholamines, lactose excessive, even can trigger lactic acidosis. to expert advice on the "diabetic lactic acidosis, induced causes, common causes," the pro Online Expert: male sexually transmitted diseases, gynecological diseases, hepatitis B skin cancer diabetes psychological


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What factors can induce diabetic ketoacidosis
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Lactic acidosis with acute onset, change fast, easy to coma, shock for the clinical features and easy. The high mortality is a serious acute complication of diabetes. The clinical presentation with coma, blurred consciousness, weakness, drowsiness and other characteristics, the lack of specificity, no rotten apple breath, it is easily overlooked, is a rare emergency, the mortality rate of not less than ketoacidosis.
Diabetes expert analysis of the reasons as follows:
1. Poor tissue perfusion or hypoxia: suffocation. Carbon monoxide poisoning, grand mal epilepsy and severe anemia and so on. all kinds of shock. Cardiogenic, hemorrhagic, endotoxin.
2. Excessive lactate production and (or) lactic acid to remove the obstacles: diabetes mellitus complicated with liver and kidney disorders. malaria, typhoid fever, severe infection, leukemia and malignancy.
3. About drugs and toxins: biguanide hypoglycemic drugs, such as phenformin, metformin. other drugs and toxins, such as isoniazid, acetaminophen (paracetamol), salicylic acid, sorbitol, xylitol, chain urinary adriamycin, sodium nitroprusside, catecholamines, ethanol, methanol, papaverine, cocaine , diethyl ether, cyanide and so on.
4. Congenital enzyme defects: congenital enzyme deficiency leads to lactic acid or pyruvate metabolism. glucose -6- phosphate dehydrogenase. fructose 1,6 - bisphosphatase. pyruvate hydroxylase. pyruvate dehydrogenase. oxidative phosphorylation enzyme defects.Concerned about diabetes, equal attention to physical health. Health Network to provide you a long time the most professional treatment of diabetes and diabetes symptoms, diabetes knowledge want to know more wonderful article, please the return of diabetes topics.
Diabetes complications - What is lactic acidosis, caused by what causes, how to prevent it?
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Abstract lactic acidosis, myocardial infarction, heart failure, leukemia, convulsions, anemia
Lactic acid is the intermediate metabolite of glycolysis lactic acid under normal conditions about 50% to 60% converted in the liver glycogen storage by about 30% to 35% of renal blood lactic acid increased by more than when 2mmol / L of blood pH less than 7.35 When no other acid poisoning can cause lactic acidosis diagnosed as a high mortality rate of this disease (50%) is one of the common cause of acute complications of diabetes can be divided into two categories: (prescription network edited)
(1) due to lack of O.2 and shock caused by such as: shock, myocardial infarction, heart failure due infection, bleeding caused by severe trauma of cardiac infectious hemorrhagic shock hypoxia asphyxia dehydration of carbon monoxide poisoning in acute pulmonary embolism and infarction pancreatitis with shock (prescription network edited)
(2) No state of hypoxia and shock caused by found: Drug biguanide hypoglycemic agents phenformin in particular were more common and serious cause another: xylitol, sorbitol, fructose, ethanol, methanol, salicylates, paracetamol streptozotocin catecholamines cyanide, ethylene glycol can cause isoniazid class systemic diseases may be associated with diabetic ketoacidosis renal failure in uremic malignant tumors of the liver disease leukemia, anemia and severe infections associated with sepsis, starvation can cause seizures in this genetic disease disease glucose -6- phosphate dehydrogenase deficiency of fructose 16 - dioxo acid enzyme deficiency pyruvate dehydrogenase deficiency pyruvate carboxylase deficiency of oxidative phosphorylation defects may also cause this disease
Therefore, the high mortality rate of this disease preventive measures taken to strengthen the following: Where do the best liver and kidney dysfunction, diabetes, heart disease biguanide hypoglycemic agent failure-prone disorder may also affect the renal circulation of drug excretion it biguanide should be used with caution to avoid the use of ethanol, methanol, isoniazid and other drugs of xylitol caution salicylate drugs such as propranolol do not use glucose, fructose, sorbitol and where in order to avoid the disease state of shock and acidosis in hypoxic liver and kidney failure should be hypoxic-ischemic correct shock to correct the basic measures to prevent the occurrence of this disease
(Prescription Online editing) more diabetes complications related content


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