Health Worlds

Exp Content Document Name: hematopoietic stem cell support of recurrent glioblastoma brain preliminary study of chemotherapy Introduction: Objective To observe their own peripheral blood stem cell support of high-dose chemotherapy, the efficacy of treatment of cerebral glioma, toxicity and feasibility. Methods 20 patients with recurrent glioblastoma patients were randomly assigned to conventional-dose chemotherapy and high dose chemotherapy own peripheral blood stem cell transplantation, chemotherapy was mainly Nemo Division Ting (ACNU) and mighty, high-dose group and conventional dose 2 times. The results of conventional dose chemotherapy in 13 cases, effective in 1 case, minor 7 cases, no change in 4 cases, 1 case of deterioration; had more severe bone marrow suppression response. 7 cases of high-dose chemotherapy, effective in 4 cases, 3 cases of minor bone marrow suppression was mild, and can quickly recover. Conclusion own peripheral blood stem cell support of high-dose chemotherapy in the treatment of recurrent glioblastoma is effective, due to resume in the short term bone marrow suppression.
Objective To study the chemotherapy and its related toxicity of glioblastomas with autologous peripheral blood stem cell support. Methods 20 patients of glioblastoma were randomly divided into 13 cases of conventional chemotherapeutic group and 7 cases of autologous peripheral blood stem cell supporting high dose chemotherapeutic group. Results There were 1 PR, 7 MR, 4 NC


, 1 PD in the conventional chemotherapeutic group, and 4 PR, 3 MR in the high dose group. Conclusion High dose chemotherapy with auto . literature under the name of hematopoietic stem cell support for recurrent cerebral Neuroblastoma Chemotherapy Study Article Name
English (English) translation Chemotherapy of glioblastomas with autologous peripheral blood stem cell support; of Lin Hua-Yi; FU Xiang-Ping; Li Anmin; Zhang Zhiwen; DU Nan; YI Linhua; FU Xiangping; LI Anmin; et alDepartment of Neurosurgery; the 304th Hospital of PLA; Beijing 100037; China;
Agencies Department of Neurosurgery of PLA, 304; People's Liberation Army No. 304 Hospital of Oncology, Beijing; Document
Article From Shanghai Institute of Metallurgy; Materials Physics and Chemistry (Professional) PhD thesis in 2000 Keywords peripheral blood stem cells; high-dose chemotherapy; glioblastoma; Keywordsautologous peripheral blood stem cell; high dose chemotherapy; glioblastomas;
Dr. Wei: My husband of a very healthy person, one month before the occasional headache. Are no other symptoms, go to hospital for examination, said that may be gliomas, "glioma" the first time I heard the term, I immediately checked the Internet, another two have not the data, my hand Start shaking the calendar harm! Glioma in the minds of terror as if and cancer. That night I cried one night, I did not talk to him, is a gross understatement to say: no big problem! Since then I have to eat very little, often sleep, wake up every day as if life as they entered the realm of nightmare! To her husband's words, I am a relatively strong, always confident woman! He always advised me not to worry. Yes, but my husband can you understand? My strength, confidence, courage that is because your spirit has been kept encouraging me to move. However . 3-year-old daughter looked at me, I'm going to completely collapse, her husband is a very cheerful, kind, gentle person, he always brought happiness to people around! I do not believe this fact, a necessary prior to the hospital, only the occasional headache only. Then went to several large hospitals, are just that gliomas can be early, and finally came to the country's most famous Beijing Tiantan Hospital, the hospital said that gliomas may be the star may be cerebral cysticercosis, probably glial hyperplasia? ? ? ? ? ? ? I'm groggy, life heard so many strange diseases, first to be a biopsy. I would like to ask Dr. Wei biopsy because they can not be confirmed that glioma it? ? ? There are even a glioma, is not supposed to be the kind of lighter? Because only occasional headaches twice before, everything else normal, had been misdiagnosed as cerebral hospitalization, treatment effect after feeling better.
Condition analysis:
At home and abroad for the treatment of gliomas is generally surgery, radiotherapy, chemotherapy, X Knife, knives.
Surgery: Surgical treatment of gliomas based on growth characteristics, in theory, surgery can not be completely removed, the growth in the brain stem and other important parts of the tumor surgery while others can not, so the only purpose of surgical treatment limited to the following five aspects clear pathological diagnosis, to reduce the number of tumor cells decreased tumor volume, to improve the symptoms of high intracranial pressure symptoms; prolong life and to create a comprehensive treatment of the subsequent timing of the other; tumor cell kinetic data obtained for the search for effective therapy.
Radiotherapy: Radiotherapy is almost routine treatment of various types of glioma, but the effects are mixed re, with the exception of medulloblastoma is highly sensitive to radiation, moderately sensitive ependymoma, other types of radiation are not sensitive, observed that the prognosis of radiotherapy and the same non-radiotherapy. In addition ray radiation induced necrosis of the brain function should not be underestimated.
X-knife, -knife - are the areas of radiation therapy because of tumor location, tumor size (usually limited to 3 cm below) and the sensitivity of tumor to the radiation treatment area limitations, currently considered gliomas, especially malignant nature of the star - grade or are not suitable for glioblastoma treatment with R-knife.
Chemotherapy: In principle, for cancer, but limited to the blood-brain barrier and drug chemotherapy side effects, efficacy is uncertain, often BCNU, CCNU, VM-26 and other effective rate below 30%.Chinese medicine treatment: Beijing Hospital Group concentric series of groups with anti-tumor medicine capsules side and application compatibility Medicines to rare animals and rare herbs selected from the development, the group based on the physiological characteristics of brain tumors and the development of heterogeneous rules , mutation of metastatic. the use of modern medicine with traditional Chinese medicine combined method to promote traditional Chinese medicine into the brain through the blood-brain barrier go fine, puncture the tumor tissue, tumor tissue closure of the blood circulation to the brain cells of normal and orderly points out, directly into the tumor play a role in phagocytic elimination, improving the brain microcirculation, the oxygen metabolism of enhanced soft focus and narrow. according to the different treatment of different conditions, observation is often differentiation stage treatment for did not have surgery or surgical partial resection, recurrence, X-knife, -knife, patients after chemotherapy, especially brain tumors caused by headache, nausea, vomiting, tinnitus, numbness, seizures, mental disorders, depending on the material unclear ghosting effect is more obvious symptoms such treatment, usually 10 to 20 days treatment can significantly alleviate or eliminate symptoms, medication after 3-6 months stable condition, most patients with tumor calcification, shrink or disappear, to prevent postoperative recurrence, clinical curative effect for many years.
Life care:
Glioma after surgery, gamma knife is easily relapse. Recommend that patients pay attention to rest. Do not be stimulated. Resuscitation appropriate aromatic vegetables to eat. Time to take medicine to prevent recurrence.


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