hemochromatosis gene mutation

20 Feb

14:47 , Via Original

academic jour World Journal of Gastroenterology "-2005 No. hereditary hemochromatosis gene mutation associated with liver disease research progress
Hereditary hemochromatosis gene mutation associated with liver disease research progress of Relationship between gene mutations of hereditary hemochoromatosis and liver diseases: UpdatesYou can in the "My Services" in the you add a reference to the notification list, and configure access to notices.Hereditary hemochromatosis is a common congenital disorder of iron metabolism. Molecular biology studies have shown that the main hereditary hemochromatosis and a chromosome 6 gene, mutations in the HFE gene. HFE gene mutations path of iron metabolism caused by the change, resulting in damage to the liver and other organs. Recent studies show that, HFE gene mutations and viral hepatitis, non-alcoholic fatty liver disease (NAFLD), liver fibrosis / cirrhosis, liver cell carcinoma (HCC) is closely related to the occurrence and development, which is of great significance. This suggests that abnormal iron metabolism, participation in various types of liver disease in the pathogenesis of HFE gene mutations not only help clarify the hereditary hemochromatosis pathogenesis, but also to other types of prevention and treatment of liver diseases. of: Shiwen Juan Cheng Jun Shi WJCheng J Shiwen Juan, Shi WJ (Gansu Province, Lanzhou Electric Co., Ltd. Hospital Liver Clinic Center, Lanzhou, Gansu Province , 730050)
Cheng Jun, Cheng J (Beiji

ng Institute of Infectious Diseases Ditan Hospital, Beijing, 100011, China) Title: World Journal of Gastroenterology ISTKU English title: WORLD CHINESE JOURNAL OF DIGESTOLOGY year, volume (period): 2005 13 (9) Classification : R5 Keywords: Machine Standard Classification: R58 R36 machine standard Key words: Hereditary hemochromatosis gene mutations in liver diseases, diseases of iron metabolism associated non-alcoholic fatty liver disease in vivo liver fibrosis in viral biology of hepatocellular carcinoma Control of the development of the pathogenesis of congenital chromosomal disease pathogenesis of multiple organ Foundation cirrhosis: DOI: References (26) Bacon BR.Powell LM.Adams PC.Kresina TF Hoofnagle JHMolecular medicine and hemochromatosis: at the crossroads 1999 Parkkila S. Waheed A. Britton RS.Feder JN Tsuchihashi Z SchatzmanRC Bacon BR Sly WSImmunohistochemistry of HLA-H, the protein defective in patients with hereditary hemochromatosis, reveals unique pattern of expression in gastrointestinal tract 1997 Cable EE.Connor JR.Isom HCAccumulation of iron by primary rat hepatocytes in long-term culture: changes in nuclear shape mediated by non-transferrin-bound forms of ir998 Falck-Ytter Y. Younossi ZM.Marchesini G. McCullough AJClinical features and natural history of nonalconholic steat

osis syndromes 2001 Sanyal AJ. Campbell-Sargent C. Mirshahi F. Rizzo WB Contos MJ Sterling RK Luketic VA Shiffman ML Clore JNNonalcoholic steatohepatitis: association of insulin resistance and mitochondrial abnormalities 2001 Dixon JB.Bhathal PS.O 'Brien PENonalcoholic fatty liver disease: predictors of nonalcoholic steatohepatitis and liver fibrosis in the severely obese 2001 Marchesini G. Brizi M. Bianchi G. Tomassetti S Bugianesi E Lenzi M McCullough AJ Natale S Forlani G Melchionda NNonalcoholic fatty liver disease: a feature of the metabolic syndrome 2001 Chitturi S. Abeygunasekera S. Farrell GC.Holmes -Walker J, Hui JM, Fung C, Karim R, Lin R, Samarasinghe D, Liddle C, Weltman M, George JNASH and insulin resistance: insulin hypersecretion and specific association with the insulin resistance syndrome 2002 Turlin B. Mendler MN.Moirand R . Guyader D, Guillygomarc'h A, Deugnier YHistologic features of the liver in insulin resistance associated iron overload.A study of 139 patients 2001 Fargion S. Mattioli M. Fracanzani AL.Sampietro M Tavazzi D Fociani P Taioli E Valenti L Fiorelli GHyperferritine iron overload, and multiple metabolic alterations identify patients at risk for nonalcoholic steatohepatitis 2001 Washington K. Wright K. Shyr Y. Hunter EB, Olson S, Raiford DSHepatic stellate cell activation in nonalcoholic steatohepatitis and fatty liver 2000 Bugianesi E. Leone N. Vanni E. Marchesini G Brunello F Carucci P Musso A De Paolis P Capussotti L Salizzoni M Rizzetto MExpanding natural history of nonalcoholic steatohepatitis: from cryptogenic cirrhosis to hepatocellular carcinoma 2002 Dimitrijevic J. Bojanic N.Skaro-Milic A. Mijuskovic P, Ilic S, Nozic DMorphologic characteristics of HBV markers and products of iron metabolism in liver tissue in patients with hepatitis B virus 2002 Farinati F. Cardin R. De Maria N. Della Libera G, Marafin C, Lecis E, Burra P, Floreani A, Cecchetto A, Naccarato RIron storage , lipid peroxidation and glutathione turnover in chronic anti-HCV positive hepatitis 1995 Cozzolongo R. Cuppone R. Manghisi OGThe treatment of chronic hepatitis C not responding to interferon 2002 Boucher E. Bourienne A. Adams P. Turlin B, Brissot P, Deugnier YLiver iron concentration and distribution in chronic hepatitis C before and after interferon treatment 1997 Meyron-Holtz EG.Ghosh MC.Rouault TAMammalian tissue oxygen levels modulate iron-regulatory protein activities in vivo 2004 Olynyk JK.Reddy KR.Di-Bisceglie AM.Jeffers LJ Parker TI Radick JL Schiff ER Bacon BRHepatic iron concentration as a predictor of response to interferon alfa therapy in chronic hepatitis C 2001 Griffiths A. Olynyk JKIron and the response to treatment of hepatitis C 2002 Kochman F. Ducrocq F. Parquet PJCyclic oro-alimentary disorders 1997 Cauza E.Peck-Radosavljevic M.Ulrich-Pur H. Datz C Gschwantler M Schoniger-Hekele M Hackl F Polli C RasoulRockenschaub S Muller C Wrba F Gangl A Ferenci PMutations of the HFE gene in patients with hepatocellular carcinoma 2003 Chao-Chun genetic pool of blood recent development of cirrhosis of the liver diseas

e [Papers] - Clinical Hepatology 2000 Blanc JF.De Ledinghen V. Bernard PH.de Verneuil H, Winnock M, Le Bail B, Carles J, Saric J, Balabaud C, Bioulac-Sage PIncreased incidence of HFE C282Y mutations in patients with iron overload and hepatocellular carcinoma developed in noncirrhotic liver 2000 Lauret E. Rodriguez M. Gonzalez S. Linares A Lopez-Vazquez A Martinez-Borra J Rodrigo L Lopez-Larrea CHFE gene mutations in alcoholic and virus- related cirrhotic patients with hepatocellular carcinoma 2002 Willis G. Wimperis JZ.Lonsdale R. Fellows IW, Watson MA, Skipper LM, Jennings BAIncidence of liver disease in people with HFE mutations 2000 Racchi O. Mangerini R. Rapezzi D. Gaetani GF, Nobile MT , Picciotto A, Ferraris AMMutations of the HFE gene and the risk of hepatocellular carcinoma 1999
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Oscar

2012/03/14 09:05

hereditary hemochromatosis is the most common inherited single-gene disorder in people of . hereditary hemochromatosis is associated with mutations in the hfe gene.

Beck

2012/03/15 04:41

recognition and management of hereditary hemochromatosis .

Melody

2012/03/18 13:17

people with a close relative (grandparent, mother, father, sibling, niece, nephew) who has hemochromatosis have a higher chance of having the hfe gene mutation.

Prima

2012/03/23 23:01

iron overload and hemochromatosis: causes and risk factors .

Quennel

2012/03/28 04:58

hemochromatosis is a single-gene disease that causes iron accumulation in the . in the case of hemochromatosis, a single gene mutation causes extra iron to be absorbed .

Phoenix

2012/04/01 06:13

hemochromatosis - american diabetes association

Ritamargaet

2012/04/07 13:57

hereditary hemochromatosis is a genetic disease that causes the body to absorb and store too much iron. several gene mutations can cause hemochromatosis.

Martha

2012/04/11 21:49

hereditary hemochromatosis - the children's hospital-denver .

Georgia

2012/04/14 11:58

the mutation for the most common form of hemochromatosis (c282y) was identified in 1996. a second mutation in this gene (h63d) has also been identified in 1-10% of patients.

Kittykitty

2012/04/21 13:26

dan mcmullin's hemochromatosis site

Angela

2012/04/23 06:16

the gene that causes hereditary hemochromatosis, called hfe, was . most cases of hh result from a common mutation in this gene, known as c282y.

Max

2012/04/27 01:43

genome.gov | learning about hereditary hemochromatosis

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