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Hereditary hemochromatosis in asymptomatic middle-aged always used, 80% to 90% of men before the onset of symptoms in patients with Zongti iron store volume 10g. Often occurs in women with symptoms of menopause, due to menstruation and pregnancy in the reduction of iron Diushi the iron overload, and thus before the age of 50 postmenopausal female patients, liver iron content is elevated. Although pregnancy and menstrual blood loss, but women may have clinical manifestations of hemochromatosis completely. Since iron overload caused by excessive clinical sequelae performance occurred in the late clinical laboratory tests in the early assessment of iron store of the best method. can be seen in female patients with early non-specific systemic symptoms such as fatigue; in males, early common cirrhosis or diabetes. iron increase the clinical manifestations of IPH may include liver cell dysfunction, liver cirrhosis, bronze skin pigmentation. diabetes mellitus (complication rate of 50% ~ 60%) and in cardiac hypertrophy, heart failure and arrhythmia or conduction block as clinical presentation of cardiac disease. pituitary Common failure and can lead to testicular atrophy and loss of libido. abdominal pain, arthritis and cartilage calcification is not common. Despite the higher incidence of diabetes prompted the family of iron is not calm the pancreas may play a factor in the mechanism, but these lesions are due parenchymal cells due to iron composure. long lasting color incidence


of hepatocellular carcinoma patients (14%), higher than any type of cirrhosis. diagnosis of hidden illness as hemochromatosis, progress is slow, variable degree of organization involved, the disease often significantly impaired in the organization of the course after the late diagnosis. and should exclude non-hereditary iron over-load, such as congenital hemolytic anemia (sickle cell anemia, thalassemia). hereditary hemochromatosis serum iron increased (10%. no load of iron during the serum transferrin level is a meaningful indicator. diabetes, heart disease, impotence and other sexual performance is secondary to the clinical indication for treatment.
Hereditary hemochromatosis is what causes?
Increase in the absolute amount of body iron and excessive deposition of iron within the organization, the following five reasons:
the regulation of iron absorption dysfunction seen in idiopathic hemochromatosis, the patient's small intestinal regulation of iron absorption have genetic defects, a day of iron absorbed from food than the quantity normally required for a day, absorbing 2 4mg (normal to 1mg), over time, several decades later, tissue iron accumulation of up to 15 ~ 50g, more than the normal tissue storage of iron in the total amount due.
erythropoietin barriers lead to anemia, and anemia and feedback manner so that significant increase in intestinal iron absorption, so more than the actual needs of the body, resulting in excessive iron deposition in tissue, a condition called erythropoietic hemochromatosis.
liver disease, chronic liver disease can occur when the blood disease, the cause is multifaceted, including the regulation of intestinal iron absorption dysfunction, leading to increased iron absorption; chronic liver disease of unknown cause can occur when the red blood cell formation and secondary barriers to anemia, lead to increased iron absorption; some patients with alcoholic liver disease, some of the high iron content in alcoholic beverages, alcohol can also stimulate iron absorption.
excessive iron content in food, the Bantu of southern Africa used to iron cooking and wine, food and wine, so a high iron content, daily up to 100mg, the patient's intestinal absorption of iron is normal , and because high concentration of iron in the intestinal tract, causing more diffusion into the mucosal cells of iron was absorbed, maintaining a positive iron balance 2 ~ 3mg, so that iron overload can occur after middle age hemochromatosis .
long-term repeated blood transfusion, a normal blood iron per 100ml of about 50mg, suffering from aplastic anemia, severe
Often asymptomatic before the middle-aged, 80% to 90% of men before the onset of symptoms in patients with total amount of iron store has 10g. Often occurs in women with symptoms of menopause, due to iron loss during menstruation and pregnancy to reduce the iron overload, Thus in 50 postmenopausal women before the age of patients, liver iron content is elevated. Although pregnancy and menstrual blood loss, but women may have clinical manifestations of hemochromatosis completely. Since iron overload caused by excessive clinical sequelae occurred in the late In early clinical evaluation of iron store of laboratory tests is the best way. In women with early visible fatigue and other non-specific systemic symptoms; in males, early common liver cirrhosis or diabetes. iron PAP clinical manifestations may include increased liver cell disorders, liver cirrhosis, bronze skin pigmentation. diabetes mellitus (complication rate of 50% ~ 60%) and in cardiac hypertrophy, heart failure and arrhythmia or conduction block as clinical presentation of cardiac disease. pituitary failure may be common cause testicular atrophy and loss of libido. abdominal pain, arthritis and cartilage calcification is not common. Despite increased incidence of diabetes prompted the family of iron is not calm the pancreas may play a factor in the mechanism, however, the parenchymal cells of these lesions are composed of iron due. long lasting color incidence of hepatocellular carcinoma patients (14%), higher than any type of cirrhosis. hemochromatosis diagnosis of the condition of the occult, progress is slow, variable degree of tissue involvement, the disease often in the organization significantly impaired the late course after the diagnosis. and should exclude non-hereditary iron over-load, such as congenital hemolytic anemia (sickle cell anemia, thalassemia). hereditary hemochromatosis serum iron increased (10%. During the no load iron, serum transferrin level is a meaningful indicator. diabetes, heart disease, impotence and other sexual performance is secondary to the clinical indication for treatment.


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