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1 liver and kidney dysfunction who were hanged there pyelonephritis biguanide diabetic nephropathy such as glomerular sclerosis, can cause build-biguanide; coronary heart disease associated with recessive renal circulation disorders such as heart failure may also affect the time excretion accompanied by hypoxia and therefore be required before use of biguanide drugs such as metformin liver and kidney function to identify the heart of the disease occurs more often than phenformin (phenformin) 2, where the shock is less apparent lack of O2 when the liver and kidney failure if acidosis must guard against the possibility of the disease prevention efforts and treatment group for A-type primary disease, and shock should be corrected for lack of O2-based treatment for B-group are as follows: 1 disable the disease induced by drugs such as various alcohols phenformin paracetamol and other 2 correct acidosis and water and electrolyte metabolism disorder in the past emphasized immediately after diagnosis by a large number of NaHCO3 in recent years to prove that in the early clinical and experimental, such as 24 hours to NaHCO3 <500mmol not only ineffective when low blood pressure can lead to pulmonary edema and lack of coma and O2 see increased anti-blood lactate increased mortality (lack of O2) so Kassier other propositions to the small dose of NaHCO3 increased HCO-3 to 4 ~ 6mmol / L and maintained at 14 ~ 16mmol / L aly, especially severe acidosis (pH <7.0 ) are not corrected unle


ss the lung function and circulation is very fast as well, otherwise difficult to exclude a result of lack of CO2 O2
Lactic acidosis should be treated?
Prevention of this disease is very important. Should note the following points:
1, liver and kidney dysfunction who were hanged biguanide. People with diabetes have pyelonephritis, glomerular sclerosis, renal disease may cause the accumulation of biguanide; associated with coronary heart disease, such as latent heart failure, kidney circulation disorder can also affect the discharge time, and accompanied by hypoxia. Therefore, before using biguanide drugs such as heart, liver function must be identified. The chance occurrence of this disease metformin than phenformin (phenformin) was significantly less.
2, where the shock, lack of O2, when the liver and kidney failure, acidosis, if any, must be alert to the possibility of the disease and prevention efforts.
A type of group treatment for primary disease and shock should be directed to correct the main lack of O2. Treatment for B-group are as follows: 1, Disable the disease induced by drugs, such as phenformin, various alcohols, such as paracetamol.
2, correct acidosis and water and electrolyte metabolism. The previous emphasis on immediately after diagnosis to a large number of NaHCO3, clinical and experimental proof of recent years, such as 24 hours in the early to NaHCO3 <500mmol when the only invalid and can lead to hypotension, pulmonary edema, lack of O2, coma, and increased mortality, blood lactate Anti-see increased (lack of O2). Therefore Kassier other propositions to the small dose of NaHCO3 increased HCO-3 to 4 ~ 6mmol / L and maintained at 14 ~ 16mmol / L is available, especially in severe acidosis (pH <7.0) are not corrected quickly, unless lung function and circulation very well, otherwise, difficult to rule out the CO2 caused by lack of O The rest of intravenous therapy with glucose and insulin on diabetes with ketoacidosis were more meaningful.
The disease mortality rate as high as 50% or more, treatment is difficult, emphasis on prevention.
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