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All treatments received the latest popular hit reply seeking advice total to be times No. of primary biliary cirrhosis type of treatment received treatment several times cholestyramine the treatment of primary biliary cirrhosis Western drug therapy Methods 10,522,502 cholestyramine treatment of primary biliary cirrhosis 15,793,400 Western drug treatment included: a total of two on the primary biliary cirrhosis treatment 1 Knowledge Base: What Primary biliary cirrhosis is Over
The disease is unexplained, chronic progressive cholestatic liver disease, may be autoimmune related.
Medical history and symptoms
The disease often associated with other autoimmune diseases such as rheumatoid joint class, Sjogren's syndrome, scleroderma, chronic lymphocytic thyroiditis and other co-exist, more common in middle-aged women, insidious onset, after a slow, early symptoms of mild Patients generally in good condition, no significant loss of appetite and weight declined more than about 10% of patients may have no symptoms. Of unexplained chronic progressive obstructive jaundice patients, especially those associated with steatorrhea, the incentive should learn more about the onset and progression of the situation, whether the existence of other autoimmune diseases, attention and secondary biliary cirrhosis cause jaundice and other liver cirrhosis were identified.
Experience Findings
Skin, sclera jaundice shows multiple scratches and scaling. Liver, splenomegaly surface is


still smooth, no tenderness.
Prevention of primary biliary cirrhosis
The disease of unknown etiology, chronic progressive cholestatic liver disease, may also be related to autoimmune drug reaction, infection and other factors related to the prevention of the disease the following way of life help:
1, absolute alcohol (including beer and wine), cutting a variety of drinks, to drink hot tea.
2, to maintain a constant daily diet to low salt, low fat, low sugar, high protein is good, do not eat spicy, greasy, fried, hard, sticky foods, not overeating, and to pay attention to food hygiene to prevent diarrhea .
Looking for expert advice with primary biliary cirrhosis treatment, please Medical A consultation asked Iraq
Keywords: primary biliary cirrhosis autoimmune liver disease
Autoimmune liver disease is the body's own immune response caused by excessive liver damage, abnormal liver function and the corresponding symptoms and signs of a group of diseases, including autoimmune hepatitis (AIH), primary biliary cirrhosis (PBC) and primary sclerosing cholangitis (PSC).
First, the differential diagnosis of autoimmune hepatitis
(A) of the viral hepatitis
Acute hepatitis similar to autoimmune hepatitis may occur after persistent, usually through the detection of anti-virus antibody (anti-HAV-IgM) can be different, but should be noted that the infection can also be seen HAV-induced autoimmune hepatitis. More difficult to pass in some chronic viral infections (hepatitis B, hepatitis C and hepatitis D virus), because in these diseases can be detected in individual cases of anti-LKM-antibody. Detection of virus infection in the index this time on the one hand, while testing some of the viral infection, and only exceptional circumstances arise autoimmune indicators, such as: ANA, SMA, SLA, LP, of great value for the differential diagnosis.
Difficult problem is the differential diagnosis of chronic active hepatitis in patients with clinical manifestations can be classified as autoimmune hepatitis, but also can detect antibodies against HCV. Often this is due to the application the first generation HCV antibody detection reagent or the ball due to the high C viremia caused by false positive results caused by the second generation with a highly sensitive detection reagents, or for examination and PCR detection of RIBA HCVRNA can be ruled out. Only a minority of patients with autoimmune hepatitis associated with the performance, while using modern serological and molecular methods detected HCV antibody positive or HCVRNA. These patients the clinical, serological and histological differences can not be infected with HCV, compared with similar men and women, their condition after a little lighter than autoimmune hepatitis, LKM-1 antibody titers lower, no response to corticosteroid therapy, does not seem special type of autoimmune hepatitis, but chronic hepatitis C virus infection associated with low titer autoantibodies.
(B) primary biliary cirrhosis
When cholestasis of primary biliary cirrhosis symptoms was not significant (the ALP and -GT is only moderately elevated, and jaundice is only mildly elevated), anti-mitochondrial antibody-negative (5% of primary biliary liver hardening AMA negative), but can be detected ANA, SMA, this time with primary biliary cirrhosis and autoimmune hepatitis identification difficult. On the other hand, must be noted that about 2% of the performance of anti-autoimmune hepatitis - mitochondrial antibodies. Early primary biliary cirrhosis duct injury can also be less obvious, can lead to tissue-specific difficulties. Such overlap cases can be differentiated only through follow-up observation.
(C) primary sclerosing cholangitis
Sclerosing cholangitis in the early or because of defects in the specimen may not be possible or that the typical stricture of bile duct fibrosis histological changes, if autoantibodies, such as ANA and SMA, the primary differential diagnosis of biliary cirrhosis caused more difficulties retrograde cholangiopancreatography (ERCP) will help to identify.
(D) Wilson disease
Wilson disease can sometimes occur ANA / or SMA, on the other hand, also seen in autoimmune hepatitis, elevated levels of serum copper, serum ceruloplasmin in low concentrations, such as seen with Wilson disease, differential diagnosis is difficult in such cases is found Kayer- Fleis-cher ring and see after the treatment with D-penicillamine and copper can increase the diagnosis of exclusion.
(E) hemochromatosis
Autoimmune hepatitis shows elevated levels of serum iron, liver iron concentration also appeared to increase moderately, on the other hand, patients with hemochromatosis can be detected occasionally autoantibodies, serum transferrin saturation and ferritin can be identified. Iron through the liver tissue iron index measured and calculated chemical can be diagnosed.
Second, the principle of treatment of autoimmune hepatitis
Principle of treatment of autoimmune hepatitis is mainly inhibition of abnormal autoimmune response, treatment indications mainly based on the degree of inflammatory activity, rather than the degree of impairment of liver function. Should the patient developed symptoms, rapid progression, or -globulin 2 times normal, and aspartate aminotransferase 5 times normal, alanine aminotransferase 10 times the normal value, etc., may consider the use of corticosteroid therapy. By the use of immunosuppressive therapy, 65% of patients receive clinical, biochemical and histological remission. Cirrhosis of the liver cirrhosis patients with and without 10-year survival rates were 89% and 90%, so it is necessary to strictly regulate the drug. The treatment of autoimmune liver disHospital of Shanghai Municipal People's Armed Police Corps was founded in 1948 in August 1982 by the Shanghai 9731248:


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