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Abstract: Objective: To investigate the autoantibodies in the diagnosis of primary biliary cirrhosis (PBC), the clinical significance. Methods: PBC and 52 patients with non-PBC patients with 202 cases, including autoimmune hepatitis (AIH) 41 cases of primary sclerosing cholangitis (PSC) 18 cases of hepatitis B (HBV) 89 cases of hepatitis C (HCV) 54 cases and 40 cases of healthy people. By indirect immunofluorescence (IIF) detection of anti-nuclear antibody (ANA), anti-smooth muscle antibodies (SMA), anti-mitochondrial antibody (AMA), anti-myocardial antibodies (HRA), anti-skeletal muscle antibody (ASA), anti-gastric parietal cell antibodies ( PCA), anti-double-stranded DNA (dS-DNA) antibody, anti-kidney microsomal antibody (LKM), anti-soluble liver antigen (SLA) antibodies and anti-neutrophil cytoplasmic antibody (ANCA) and other autoantibodies, ELISA method Detection of antibodies against myeloperoxidase (MPO). And the results were analyzed retrospectively. Results: PBC patients with AMA positive cases up to 46 cases (88.5%), ANA positive rate was 71.2% (37/52); non-PBC patients with positive cases were 20 cases (9.9 %) and 51 patients (25.2%), the two groups, there are very significant (P 0.01). Conclusion: Serum autoantibodies in the diagnosis, treatment, and prevent the development of primary biliary cirrhosis has a very important role. PBC with other diseases to improve diagnosis and treatment has a very important significance.
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Hepatomegaly 1, right heart failure caused by any reason, right heart failure can be significantly increased in the venous pressure, jugular vein engorgement, hepatic positive jugular reflux symptoms significantly expanded the heart, pulse weakened, swollen liver and hilar vascular shadow was great tenderness, cards can be mild swelling, jaundice and rare or mild chest without varicose veins, lower extremity edema, ascites, a small amount of slow growth, the appearance of yellow transudate. Hepatomegaly is characterized by increased heart failure when the failure time increased significantly after better retraction. Methyl phthalate Australia increased sodium retention, urine Urobilinogen displacement increases in serum alanine aminotransferase normal. B-ultrasonic examination showed hepatic vein dilation.
2, chronic constrictive pericarditis, tuberculous pericarditis often past, purulent pericarditis, viral pericarditis, or cardiac trauma history has been significantly jugular vein filling, venous hypertension, there are odd jugular vein reflux liver The positive sign of a normal or slightly larger heart, heart beat was significantly weakened, distant heart sounds with pericardial knock sound. Hilar vascular X-ray film showed a clear, normal pericardium or pericardial calcification profile changed significantly enlarged liver, pain, mild swelling of licensing can be normal or mildly abnormal liver function.
3, Parkinson syndrome investigated high incidence of males aged 20-45. Caused by hepatic vein or the inferior vena cava obstruction in the etiology, location, scope, extent and duration of disease onset Jihuan there are differences between different clinical manifestations. The rapid emergence of acute liver pain, progressive hepatomegaly, ascites is characterized by rapid growth, abdominal vein dilation, with varying degrees of liver impairment showed severe shock or liver failure rapid death. In addition to some patients in chronic phase transferred from the acute stage, most symptoms were insidious onset and slow signs of the emergence of diseases of the elderly splenomegaly and esophageal varices, inferior vena cava obstruction chest. Abdominal venous engorgement is very clear, bottom-up flow direction of bilateral lower extremity edema, calf skin, brown pigment spots, severe varicose veins or ankle and foot ulcers occur nutrition, bilateral lower extremity venous hypertension. Only mild liver damage with mild sulfur Australia Test phthalocyanine sodium retention, elevated alkaline phosphatase. B-ultrasound can show the size of the inferior vena cava diameter to determine whether the stenosis or obstruction, and the location and extent of obstruction, liver and spleen size and shape, with or without ascites. Increased radionuclide liver scan forms of liver disorders, congestive heart hypertrophy of tracer accumulation in the caudate lobe, was "the central concentration" in the right lobe-shaped distribution of the tracer was sparse or significantly reduced. Angiography can determine the site of obstruction. The nature and extent of the range, not only provides important diagnostic evidence, and for the clinical classification and select the correct surgical technique is essential to provide an important basis for the examination.


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