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Primary biliary cirrhosis can be cured? How the treatment of primary biliary cirrhosis? Which hospital treatment effect of primary biliary cirrhosis? Many patients ask, primary biliary cirrhosis of unknown etiology, patients with cirrhosis of the liver could not find a new method of governance, and even low self-esteem, lost confidence in life. So on these issues, we invite experts in the Jinan Union liver disease hospital to answer your questions, let you back in life a ray of sunshine.
Primary biliary cirrhosis is how is it? Primary biliary cirrhosis What are the symptoms?
Concord Hospital, Jinan, liver specialists, primary biliary cirrhosis by intrahepatic bile duct an inflammatory destruction of intrahepatic cholestasis characterized by chronic liver disease, often accompanied by a variety of immunological abnormalities, the incidence may be related to the immune abnormalities. Typical clinical manifestations are, diagnosis, and more without difficulty, but this time the disease is more advanced, so early diagnosis is to determine the treatment success and failure. With the launching of sensitive detection methods, asymptomatic, primary biliary cirrhosis without jaundice early diagnosis gradually increased. Concord Hospital, Jinan, liver liver specialist Fandian Ying said: In response to this disease, the most effective treatment is bone marrow stem cell transplantation.
Primary biliary cirrhosis can be cured? How the treatment of primary biliary cirrhosis


? Autologous bone marrow stem cell transplantation refers to the patient's own bone marrow stem cells transplanted into the body, so the growth and reproduction, repair damaged liver cells, the re-establishment of normal liver function a cure. Many people will not dare to try, or that there is no effect of the new method, today we speak with the facts. It is understood that, for chronic liver cirrhosis, liver failure patients, conventional treatment does not cure cirrhosis, ten years did not reduce mortality in patients with liver cirrhosis is still high as 40% to 50%, even though liver cirrhosis is still under control will relapse. The stem cell transplantation for treatment of cirrhosis of the liver total efficiency above 85%.
Which hospital treatment effect of primary biliary cirrhosis? Concord Hospital, Jinan, liver disease has advanced medical research facilities, bringing together domestic and international cell research and clinical experts, and has successfully held several international academic conferences. One of the few in the world to provide leading edge clinical services and stem cell research, one of the cell biology research. Stem cell treatment centers with the hospital has the world advanced workshop and cell separation, incubation, training, equipment proliferation, while have experienced experts operation, strict sterile cell extraction, high precision and advanced technology for detection. We have successfully carried out for many patients, autologous bone marrow stem cell transplantation, a significant curative effect in patients without any side effects, and the immune parameters of patients were improved.
Union Hospital of Jinan liver transplantation of autologous bone marrow stem cells of primary biliary cirrhosis, in life you get back a ray of sunshine.
Keywords: primary biliary cirrhosis autoimmune liver disease
Autoimmune liver disease is the body's own immune response caused by excessive liver damage, abnormal liver function and the corresponding symptoms and signs of a group of diseases, including autoimmune hepatitis (AIH), primary biliary cirrhosis (PBC) and primary sclerosing cholangitis (PSC).
First, the differential diagnosis of autoimmune hepatitis
(A) of the viral hepatitis
Acute hepatitis similar to autoimmune hepatitis may occur after persistent, usually through the detection of anti-virus antibody (anti-HAV-IgM) can be different, but should be noted that the infection can also be seen HAV-induced autoimmune hepatitis. More difficult to pass in some chronic viral infections (hepatitis B, hepatitis C and hepatitis D virus), because in these diseases can be detected in individual cases of anti-LKM-antibody. Detection of virus infection in the index this time on the one hand, while testing some of the viral infection, and only exceptional circumstances arise autoimmune indicators, such as: ANA, SMA, SLA, LP, of great value for the differential diagnosis.
Difficult problem is the differential diagnosis of chronic active hepatitis in patients with clinical manifestations can be classified as autoimmune hepatitis, but also can detect antibodies against HCV. Often this is due to the application the first generation HCV antibody detection reagent or the ball due to the high C viremia caused by false positive results caused by the second generation with a highly sensitive detection reagents, or for examination and PCR detection of RIBA HCVRNA can be ruled out. Only a minority of patients with autoimmune hepatitis associated with the performance, while using modern serological and molecular methods detected HCV antibody positive or HCVRNA. These patients the clinical, serological and histological differences can not be infected with HCV, compared with similar men and women, their condition after a little lighter than autoimmune hepatitis, LKM-1 antibody titers lower, no response to corticosteroid therapy, does not seem special type of autoimmune hepatitis, but chronic hepatitis C virus infection associated with low titer autoantibodies.
(B) primary biliary cirrhosis
When cholestasis of primary biliary cirrhosis symptoms was not significant (the ALP and -GT is only moderately elevated, and jaundice is only mildly elevated), anti-mitochondrial antibody-negative (5% of primary biliary liver hardening AMA negative), but can be detected ANA, SMA, this time with primary biliary cirrhosis and autoimmune hepatitis identification difficult. On the other hand, must be noted that about 2% of the performance of anti-autoimmune hepatitis - mitochondrial antibodies. Early primary biliary cirrhosis duct injury can also be less obvious, can lead to tissue-specific difficulties. Such overlap cases can be differentiated only through follow-up observation.
(C) primary sclerosing cholangitis
Sclerosing cholangitis in the early or because of defects in the specimen may not be possible or that the typical stricture of bile duct fibrosis histological changes, if autoantibodies, such as ANA and SMA, the primary differential diagnosis of biliary cirrhosis caused more difficulties retrograde cholangiopancreatography (ERCP) will help to identify.
(D) Wilson disease
Wilson disease can sometimes occur ANA / or SMA, on the other hand, also seen in autoimmune hepatitis, elevated levels of serum copper, serum ceruloplasmin in low concentrations, such as seen with Wilson disease, differential diagnosis is difficult in such cases is found Kayer- Fleis-cher ring and see after the treatment with D-penicillamine and copper can increase the diagnosis of exclusion.
(E) hemochromatosis
Autoimmune hepatitis shows elevated levels of serum iron, liver iron concentration also Chuxian moderate increase, on the other hand, patients occasionally haemochromatosis detection of autoantibodies, serum transferrin saturation and ferritin can be identified. Iron through the liver tissue iron index measured and calculated chemical can be diagnosed.
Second, the principle of treatment of autoimmune hepatitis
Principle of treatment of autoimmune hepatitis is mainly inhibition of abnormal autoimmune response, treatment indications mainly based on the degree of inflammatory activity, rather than the degree of impairment of liver function. Should the patient developed symptoms, rapid progression, or -globulin 2 times normal, and aspartate aminotransferase 5 times normal, alanine aminotransferase 10 times the normal value, etc., may consider the use of corticosteroid therapy. By the use of immunosuppressive therapy, 65% of patients receive clinical, biochemical and histological remission. Cirrhosis of the liver cirrhosis patients with and without 10-year survival rates were 89% and 90%, so it is necessary to strictly regulate the drug. The treatment of autoimmune liver disHospital of Shanghai Municipal People's Armed Police Corps was founded in 1948 in August 1982 by the Shanghai 9731248:


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