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Xinhua Tokyo Nov. 27 (Xinhua Ho Gong) treatment of difficult diseases in Japan Medical Research Center, led by Associate Professor Nakajima Limbaugh team found, called "SYNOVIOLIN" excess enzyme, is caused by rheumatoid joints inflammation of the reasons, the results go a long way in developing new drugs.
27 Nakajima Limbaugh accepted Xinhua News Agency reporters Cai Fangshi and Jie Shaoshui, the clinical manifestations of rheumatoid arthritis synovial membrane is a chronic inflammation of joints, accompanied by the overgrowth of synovial cells, in medicine called "slip membrane proliferation, "the proliferation of synovial cells invade and eventually destroy articular cartilage and bone. Clearly, understanding the factors that regulate synovial hyperplasia of rheumatoid arthritis pathology that causes the key.
Nakajima Limbaugh rheumatoid arthritis research from 5 years ago, through his careful analysis of the synovial membrane of patients with rheumatoid arthritis and found that the "SYNOVIOLIN" over-active enzymes. Then, in the island of Limbaugh and others bred by transgenic technology 23 "SYNOVIOLIN" excess mice, the results of these abnormal proliferation of synovial cells in mice, all of spontaneous rheumatoid arthritis. These results suggest that "SYNOVIOLIN" a great relationship with rheumatoid arthritis.
Nakajima Limbaugh said, synovial cells can synthesize a lubricant on the joints of collagen, and rheumatoid arthritis patients because "SYNOV


IOLIN" surplus, synovial cell proliferation, excessive collagen synthesis, and thus susceptible to joint tissue contusion, causing inflammation. Mr. Nakajima that, if we can inhibit the "SYNOVIOLIN" role, may have effects on all patients with rheumatoid arthritis. He plans to use the results started to develop new drugs and gene therapy, in a few years put into practical use.
Rheumatoid arthritis is a reason unknown to joints and tissues around joints mainly non-infectious chronic inflammatory systemic disease, can lead to destruction of cartilage and bone, and then cause joint stiffness, deformity and loss of function. Medical science has largely suppressed by cytokine treatment of rheumatoid arthritis drugs, but the method of three tenths of patients had no effect. (End) User name Password Anonymous
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