Health Worlds

Wang, 35, is a wine country hero. Drunk drink every day, bulging belly has had several big history of vomiting blood. One day, Pharaoh's wife thought he bacchanal, and sent him to the emergency room, the Pharaoh cried that his eyes could not see. His wife is not impressed, Pharaoh again insane madness, and emergency room physicians like Detective Conan play his keen sense of smell, to the Pharaoh detection methanol concentration, methanol poisoning really is.
Can be seen in daily life where alcohol?
Methanol is an odorless, colorless, by the evaporation of the toxic wood alcohol. Generally common in antifreeze, windshield glass cleaners, paint, leather, dyes, film and other insects, and is often added to industrial alcohol or as alcohol lamp fuel.
Methanol poisoning generally the most common drink was drank fake alcohol or industrial alcohol suicide.
The symptoms of methanol poisoning (in the use of methanol poisoning generally occurs after 12 hours)
Gastrointestinal symptoms: nausea, vomiting, stomach pain.
Central nervous system symptoms: dizziness, headache, dizziness, ataxia, confusion, convulsions, coma.
Eye symptoms: double vision, blurred vision, vision reduced, facing a dance-like points of light or flash, as if into a blizzard, and even blindness.
Severe metabolic acidosis caused by breathing difficulties.
Other: such as pancreatitis, ion imbalance, rhabdomyolysis, acute renal failure.
Serious and even lead to shock and death.
The


treatment of methanol poisoning
Supportive therapy: including gastric lavage, treatment of acid poisoning, endotracheal intubation be necessary.
Alcoholism (ethanol: Shaoxing 5ml/kg st, then1ml/kg/hr): generally have symptoms, the blood methanol concentration greater than 20mg/dl, 40% methanol ingestion of more than 0.4ml/kg, who need dialysis, both to be ethanol treatment.
Dialysis: the eyes or central nervous symptoms, severe acidosis, blood methanol concentration greater than 50mg/dl, 40% of ingestion of more than 30ml of methanol required dialysis.
Condition analysis:
Methanol mainly absorbed through the respiratory tract and digestive tract, the skin can also be partly absorbed, absorbed quickly distributed in various tissues and organs, content and directly proportional to the water content of tissues and organs. Methanol oxidation in the body and are slowly excreted, it is obvious accumulative . not the oxidation of methanol, the main pulmonary respiratory discharge (approximately 14% of the amount to enter, but also by the kidneys (about to enter the amount of 30%) discharged, there may be a small part of the slow discharge of the gastrointestinal tract. The person I large individual differences in toxicity, usually 5 ~ 10ml can cause severe poisoning, the lowest 7 ~ 8ml can cause blindness, lethal dose of 30ml or so. inconsistent with the consequences of intoxication, some more than 20ml of oral lethal; 15ml lead to permanent blindness, but have oral 250ml and rescued survivors. The mechanism of methanol poisoning, the oxidation products of the new eco-formaldehyde or formate and the combination of proteins within the cell caused by damage to the main body of the central nervous system significant narcotic effect. Although the narcotic effect of ethanol than the weak, but because of its oxidative metabolism of slow accumulation and strong, so the toxic effects of ethanol than is big; the anesthetic concentration and the lethal concentration is closer, so the risk is also greater.
Suggestion:
. optic nerve and retina of a special selection. Eye tissue water content, hence the high content of methanol poisoning, generated by the oxidation of alcohol dehydrogenase, formaldehyde, about 33 times more toxic than methanol, which acts on the retina glycogen glycolysis enzyme to damaged mitochondria, cytochrome oxidase is inhibited, thereby inhibiting the process of oxidative phosphorylation the retina, the membrane can not generate ATP, causing cell degeneration, lead to the retina and optic neuropathy, and ultimately lead to optic atrophy. In addition, methanol metabolism in the formation of formic acid, methanol toxicity than about 6 times, it can inhibit some of the oxidase, and cause acidosis; formate can still be induced neural axoplasmic flow barriers, but also to aggravate retinopathy factors. metabolic acidosis. formic acid accumulation in the body, together with methanol in the body can inhibit some of the oxidase system, the aerobic decomposition of the sugar and the body metabolism disorder, leading to lactic acid and other organic acids accumulate in the body , causing metabolic acidosis.



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