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Xinhua Beijing on October 27 Xinhua Beijing Union Medical College Institute of Basic Medical Pharmacology, researchers Guo Lei recently written that more than 50% of diabetic patients will be "neuropathy."
Guo Lei said that 81% of diabetic patients to pay the treatment costs are used in the control of diabetes complications above. Research shows that 10 years after the onset of diabetes, 30% -40% of the patients had at least a complication occurs. With the extension of disease, neuropathy prevalence rate of 50% or more.
Diabetic peripheral neuropathy (DPN) is the result of chronic hyperglycemia in diabetes, due to various pathological changes caused by physical injury of the nervous system, peripheral nervous system the body can affect any part of this group is the most common disease of diabetes, the most complex , the most easily overlooked complications.
Guo Lei suggested that the absence of obvious symptoms of peripheral neuropathy in diabetic patients, can take the initiative to test:
Check the temperature sensation: the glass into cold water and warm water, respectively, and then Beibi foot with the skin, cool thermal sensation assessment. If you do not feel that the loss of temperature sensation.
Check the protective external sense: with a special nylon yarn 10g big toe and foot with different parts, such as patients with no feeling, it is considered abnormal.
Tuning fork vibration sense testing: application of 128Hz tuning fork placed on the pa


tient's feet on the toe, if the patient feels the vibration of the tuning fork causes reduced or lost, you will be prompted nerve lesions occur.
Joint position sense tests: the distal fingers and toes for up or down, close your eyes if the patient can not recognize such a joint after the move, you should check the most recent joint, for example, if the patient can not identify the toe joint Action should check the ankle joint position.
Guo Lei, said a specific complication of diabetes, be sure to find the cause of the right medicine. Unified theory proposed mechanism of diabetic complications, excessive mitochondrial superoxide, including DPN is the leading chronic complications of diabetes, including the common mechanism. Thus, anti-oxidant in the treatment of DPN and more attention, such as -lipoic acid (Austria Lippo), and other drugs, it can reduce lipid oxidation of nervous tissue to prevent the role of protein glycosylation sugar, alleviate diabetes Xiangguan of neuropathic pain.
U.S. Mayo Clinic neurologist 120 patients were randomly divided into two groups were treated 5 times per week 600mg of the Austrian Lippo intravenous placebo or invalid, the result is only a half weeks after the Lippo Group that Austrian symptoms has been significantly improved, for example, reduced pain for six points lower over the same period the control group only two points. Beijing Union Medical College Hospital and other hospitals to carry out the treatment of DPN on the Austrian Lippo Clinical research has also been a positive effect.
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Distant effect of cancer caused by nervous system dysfunction, no direct violation of neural tissue cancer, infection or neurological evidence of vascular complications. Paraneoplastic syndrome occurring in the "1% of cancer cases, which is large most of lung cancer (oat cell lung cancer usually), breast cancer or ovarian cancer cases. is not limited to various paraneoplastic neurological syndromes, but often involving the nervous system. etiology is unknown. in some cases found in the blood circulation there are antibodies against the nervous system, it was suggested that some of the paraneoplastic syndrome is an autoimmune mechanism. syndrome classification is based on the positioning of the symptoms. tumor distant effects on the central nervous system of progress can be expressed as dementia, mood changes, seizures, and rare focal motor or sensory signs. in some cases in the medial temporal lobe during assembly of lymphocytes (the limbic system encephalitis); while in other cases what is seen exception. on the impact of the peripheral nervous system can be expressed as weak (sometimes Eaton-Lambert syndrome) and peripheral neuropathy. diagnosis is by exclusion of other diseases can be determined, unless the patient's serum or cerebrospinal fluid of characteristic autoantibodies found . differential diagnosis, including metabolic brain disease, meningeal cancer patients as well as progressive multifocal leukoencephalopathy. paraneoplastic syndrome no special treatment, although occasional cases of cancer in the primary condition improved after treatment. special Subacute cerebellar syndrome caused by progressive degeneration of both upper limbs and lower limbs ataxia, dysarthria, and sometimes dizziness and diplopia. the nervous system's performance can include dementia, with or without brain stem signs, eye muscle paralysis, nystagmus and the plantar reflex extension of the program (Babinski sign), with significant dysarthria and upper limb ataxia. diseases usually progress in a few weeks to several months during the period increased, often resulting in serious functional movement disorder. cerebellar degeneration can before the cancer was discovered in a few weeks to several years. In some cases, especially female breast or ovarian cancer patients can be found in the serum or CSF anti-Y antibody, which is a presence of autoantibodies in the circulation. MRI or CT may show cerebellar atrophy, particularly in advanced disease. characteristic pathological changes include extensive Purkinje cell loss, and deep perivascular infiltrate of lymphocytes ("cuff" phenomenon). cerebrospinal fluid occasional mild lymphocytosis syndrome. no special treatment, but in some cases after successful cancer treatment may have the disease improved. paraneoplastic sensory neuron disease, with or without encephalitis is found in small cell lung cancer . Clinical signs include painful sensory neuropathy, all feeling is gone. cerebellar degeneration and brain stem abnormalities variable. limbic system encephalitis begins as anxiety and depression, progress to memory loss, agitation, confusion, hallucinations and abnormal behavior . Some cases can be found in serum or CSF anti-Hu autoantibodies. no special treatment of this disease, and occasional cases of the disease after treatment in cancer progress. eye clonic (spontaneous, chaotic eye movements) is a cerebellar syndrome, a rare species may occur in children with neuroblastoma. may be associated with the trunk and limb cerebellar ataxia and myoclonus. can be found circulating anti-Ri autoantibodies. on the primary tumor adrenocorticotropic hormone treatment and can often play a good effect. sub acute motor neuron disease is a rare disease, causing bilateral upper and lower limbs painless weakness of lower motor neurons, usually occurs in Hodgkin's disease or other lymphoma cases. degeneration of the spinal anterior horn cells. usually spontaneous condition improved. Subacute necrotizing myelopathy is rare. occurred within the spinal cord gray matter and white matter rapidly rising loss of sensory and motor function, leading to both lower extremities paralysis. MRI can help exclusion caused by metastatic tumors in the epidural compression (the rapid progress of cancer cases caused by spinal cord dysfunction is much more common causes). MRI scan, revealed necrotic lesions. Peripheral neuropathy is a cancer of the nervous system The most common form of distant role. is usually a distal sensorimotor polyneuropathy, showed mild motor weakness, sensory loss and distal tendon reflex. the syndrome and many chronic diseases associated with the distal polyneuropathy is unable to make a difference, there may be due to nutritional deficiencies, but the syndrome's effect on the poor treatment of nutritional supplements. Subacute sensory neuropathy is a more special and rare peripheral neuropathy. dorsal root ganglia degeneration, causing progressive loss of sensation and sensory ataxia, and no movement weakness; the disease can cause serious functional movement disorder. In some patients with lung cancer can be found in the serum anti-Hu autoantibodies. no special treatment of this disease. In Hodgkin's disease, the Guillain - Barre syndrome in the general population than the more common. Eaton-Lambert syndrome (myasthenic syndrome) is a species by immune mediated syndrome similar to myasthenia gravis, muscle weakness usually affects the extremities, not involving the disposal of ocular and bulbar muscles. lesions located in the presynaptic, nerve terminals due to the release of acetylcholine at the obstruction caused by . and IgG antibodies related. the most common cancer in men with chest cases (70% of small cell or oat cell lung cancer.) signs and symptoms include easy to fatigue, weakness, sometimes with proximal limb muscle pain, around the of paresthesia, dry mouth, impotence and ptosis. tendon reflexes diminished or disappeared. repetitive nerve stimulation increased reaction confirm the diagnosis: Applica 10Hz repetition of electrical stimulation can increase muscle action potential ampli 200%. Treatment should be the first for basic cancer, the treatment of the latter can sometimes induce remission. GuHCl (start 125mg, orally, 4 times a day, gradually increasing to a maximum dose of 35mg/kg) could promote the release of acetylcholine, often can reduce clinical symptoms, but inhibit the bone marrow and liver functions. adrenal cortex hormones with plasma replacement therapy beneficial for some patients. dermatomyositis and polymyositis to a lesser extent in the cancer cases are considered in the normal population is more than is common, especially older than 50 years of age. typical symptoms of progressive increase of proximal muscle weakness, muscle biopsy showed inflammation and necrosis. cheek may appear dim, and erythema-like, butterfly-shaped rash, with lavender, with periorbital edema. adrenocorticotropic hormone may help.


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