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Cited reference with China Academic Journal ago 10 1 Cui Wenli, Wang Chih-cheng, Transport Cooperation, Chen Mei, GUO industry, Jean; Compound Leech Capsule Clinical treatment of uterine fibroids [J]; of Traditional Chinese Medicine; 2000 06 2 Xiazi Huang; "gynecology Xiaoliu film" Clinical observation of treatment of uterine fibroids [J]; Shanghai Traditional Chinese Medicine; 2000 08 3 Shenglu Wen; eliminate tumor agent Bag 186 cases of uterine fibroids [J]; China in Pharmaceutical Technology; 1999 05 4 ZHOU Jing, Jinfeng Li, easy to repair Jane; Xiaoliutang 30 cases of uterine fibroids clinical experience before and after treatment of hair trace elements [J]; of Traditional Chinese Medicine; 02 2000 of 5 Sheng Li, Yanhua Qu, Wang Jingxi, Yao Wei, Wang Ke, He Puren; fire needle therapy clinical observation of 50 cases of uterine fibroids [J]; Chinese acupuncture; 1998 03 6 Ma Liya, Wang Jinhua, high Sulan, Lu Ximing ; women's health vaginal disease treatment clinical study of 82 cases of uterine myoma [J]; of Traditional Chinese Medicine; 1999 03 7 TRADITIONAL FORMULAE Zhengqi Chang, Fu Lingmei; Qi Stasis on the uterus NK cell activity in patients with fibroids impact study [J]; Chinese Medicine and Pharmacology; 1999 05 8 Zhou Jun, Zhu, Li Yu Xing, Shi Jianrong, Yuanming Fang, Chen Zhong Li, yellow with the British; removing tumor cells in patients with uterine fibroids used to improve immune function Clinical and experimental study [J]; Journal of Traditional Chin


ese Medicine; 1997 05 9 weeks dragonfly, Jinfeng Li, Yi Xiu Zhen; TCM Syndrome uterus, infertility induced cell stasis pulse data analysis of 56 cases [J]; Journal of Traditional Chinese Medicine; 1999 02 10 Yu-min, Li Donghua, Ye Weicheng; tumor tablets in the treatment of uterine fibroids net experimental study [J]; China Medical University; 2002 05
Condition analysis:
Uterine fibroids (Hysteromyoma), also known as uterine fibroids, is the most common form of female genital benign. More asymptomatic, a few expressed as vaginal bleeding, abdominal mass, and pressure symptoms hit. In case of torsion, or other situations can cause pain. with multiple uterine fibroids common. The exact cause of this disease is unknown, modern Western medicine to take hormones or surgery, there is no other satisfactory treatment.
Suggestion:
1, LHRH agonists (LHRH-A): that in recent years a new type of anti-GnRHa gynecological disease drugs. LHRH large number of continuing applications, the pituitary cell receptor can not be filled by hormone synthesis and release of FSH and LH; In addition, LHRH are outside the role of the pituitary, the ovaries after a large dose of LHRH receptors on the increase, reduce ovarian production of estrogen and progesterone skills. As the drug significantly inhibited FSH, reduced ovarian hormone secretion, and its role like "drug-induced ovarian removal" to make muscle tumor shrinkage. LHRH and LHRH-A for the same work heterogeneity, but the latter several times higher activity than the former.
Usage: LHRH-A, multi-IM, can also be used for subcutaneous implantation or injection into the nasal. Since the first day of menstruation intramuscular 100 ~ 200 g, for 3 to 4 months. Its effect depends on the applied dose, route of administration and the time of the menstrual cycle. fibroids after treatment reduced from 40 to 80% on average, symptoms, anemia corrected. Serum E2 decreased consistent with the fibroids shrink. FSH.LH no significant change. discontinuation grow again soon after the fibroids , suggesting that the role of LHRH-A is fleeting and reversible. as for the perimenopausal period, in a finite time to reach natural menopause. such as those used to preserve fertility, when fibroids shrink, local blood flow, thus reducing surgery the bleeding and reduce the extent of surgery; or the original mouth of oviduct fibroids, fibroids shrink after treatment of tubal patency does not change the smooth and improve the pregnancy rate. In order to reduce fibroids re-grow after treatment, when the use of LHRH-A, sequential application of medroxyprogesterone acetate 200 ~ 500mg, can maintain its efficacy.
Side effects as hot flashes, sweating, vaginal dryness, or bleeding disorders. Due to low estrogen may have osteoporosis possible.
2, Danazol: a weak androgen. Danazol suppression of hypothalamus and pituitary function, so FSH.LH drop, thereby suppressing ovarian steroid production, can also directly inhibit the production of ovarian steroid enzymes. So that the estrogen levels drop inhibition of uterine growth, endometrial atrophy and amenorrhea. Meanwhile, smaller fibroids are shrinking. But the young player application, resume menstruation after 6 weeks of withdrawal. so need to repeat the application.
Usage: 200mg, 1 3 times a day orally, starting from the second day of menstruation for 6 consecutive months.
Side effects as hot flashes, sweating, weight gain, acne, liver SGPT increased (check liver function before and after treatment). Discontinuation restore 2 to 6 weeks.
3, Gossypol: is made from cottonseed in a double aldehyde naphthalene compounds act on the ovaries, no inhibition of the pituitary, atrophy of the endometrium has a specific role, but also on the inhibition of membrane receptors on uterine muscle cells degradation effects have resulted in false menopause and uterine contraction. This drug has the reputation of China Danazol for the treatment of uterine fibroid symptoms and effective rate was 93.7%, 62.5% for the fibroids shrink.
Usage: 20mg, 1 daily oral dose, and even served for 2 months. After the 20mg, 2 times per week, and even served for 1 month. 1 week 1 after another, and even served a month for 4 months. For cotton row of phenol renal side effects of potassium, it should pay attention to the liver, kidney function and potassium situation. gossypol usually required 10% of potassium citrate plus services. recovery of ovarian function after treatment.
4, vitamins: The vitamin treatment of uterine fibroids is that it can reduce the myometrium of the estrogen sensitivity of the neuroendocrine system of regulation, so that the normalization of the metabolism of steroid hormones to promote the Soviet Union fibroids shrink .1980 mainly reported to vit A, plus vit B, C, E and other comprehensive treatment of small fibroids, the effect of 80%, and no side effects. Domestic package rocks also trial the cure rate was 71.6%, this method is suitable for small fibroids .
Usage: vit A150, 000IU, XV ~ twenty-six days since menstruation, daily oral administration. Vit Bco1 slices 1, 3 times, since the period fourteen days of oral V ~. Vitc, 0.5, 2 times a day, since the XII ~ twenty-six days menstrual oral. vit E 100mg, 1, 1, in the fourteenth ~ the 26th menstrual oral, serving a total of 6 months.
5, the male hormones: estrogen confrontation, control uterine bleeding (menorrhagia) and prolonged menstrual cycles.
Usage: methyl testosterone 10mg, sublingual, 1 day, even for 3 months. Or menstrual clean start after 4 to 7 days, daily intramuscular injection of testosterone propionate 1 times 25mg, for 8 ~ 10, will receive hemostasis. long-term for the male hormone testosterone phenylacetate, testosterone propionate stronger role than 3 times, 150mg injection of 1 or 2 times a month. typically will not appear masculine, even if there is, after stopping symptoms disappear naturally. androgen application should be in 6 months or less, for then, should be stopped after 1 to 2 months.
Dose above the long-term administration, no side effects and more. Postmenopausal women in the past can stop bleeding menopause. Androgen after by not only can stop the growth of fibroids, but also make 1 / 3 to 1 / 2 in patients with fibroids degradation, shrinking smaller. due to salt and water retention testosterone, so the heart failure, cirrhosis, chronic nephritis, edema, etc. should be used with caution in patients with or hanged. As some scholars believe that the incidence of fibroids may also be androgen For, so some do not tend to androgen.
6, progesterone: progesterone to some extent, estrogen antagonist, and inhibit its function, so some scholars associated with progestin therapy of uterine fibroids follicular persistence. Progestin commonly used are: MPA (medroxyprogesterone acetate), Women Tablets (megestrol acetate), Women Tablets (norethindrone) and so on. line according to the specific situation of patients continuing treatment cycle or pseudopregnancy therapy, the fibroid degeneration, softening. but because of irregular uterine bleeding and can increase the tumor, not long-term use.
MPA: periodic treatment for daily oral 4mg, Sixth ~ twenty-five days from the oral period. Maintenance therapy: the first week of 4mg, 1 3 times a day orally, the second week of 8mg, 1 to 2 times. After the 10mg, 1 2 times. are continuous application of 3 to 6 months. also with 10mg, 1 3 times a day, even for 3 months.
Women's Tablet: periodic treatment for daily oral 5 ~ 10mg, twenty-five days from menstruation or sixteenth sixth ~ ~ on the 25th. Continuing treatment for the first week of the 5mg, 1, 1, the second week of 10mg, 1, 1. after the 10mg, 1 to 2 times. are applied 3 to 6 months.
7, tamoxifen (tamoxifin, TMX): TMX to double styrene derivatives, as a non-steroidal anti-estrogen drugs. It is through competitive binding of cytosolic ER to form TMX-ER complexes, transportation to long-term retention within the nucleus. TMX before acting on the pituitary, thereby affecting the ovaries, while there are direct effects on the ovary. TMX better on the ER-positive.
Usage: 10mg, 1 3 times a day orally, and even served as a course of 3 months. Side effects of mild hot flashes, nausea, sweating, menstrual delay.
8, leukotriene high quinolone (R2323): that the PR (nemestran), 19 to a testosterone derivative, has strong anti-estrogen effect, it inhibits pituitary FSH, LH secretion, the decline in estrogen levels , shrink the uterus, mainly for the treatment of uterine fibroids.
Usage: 5mg, 3 times a week, vaginal, should long-term use, to prevent the increase of uterine rebound. Early treatment for 6 months, efficacy of good, the uterus was significantly reduced. Side effects as acne, hot flashes, weight gain.
In patients with bleeding of fibroids, bleeding more, uterine contraction can be used or oral medication, intramuscular injection of hemostatic agents. As Leonurus liquid extract, Motherwort extract, oxytocin, ergometrine and so on. Hemostatic blood rather have women, three seven, bleeding sensitivity, bleeding aromatic acid, tranexamic acid, 6 - amino acid and so on. calcium can increase the excitability of uterine muscle tone and blood coagulation performance, but also to try. such as 10% calcium gluconate intravenously 5 ~ 10ml, or 5% liquid calcium chloride 30 ~ 35ml warm enema.
9, consumers end capsule blood circulation, Endometriosis, uterine fibroids due to blood stasis syndrome who see the above. Orally, 2 capsules 3 times a day; or doctor.
10, Palace of tumor capsule Endometriosis, blood circulation, strengthening and restoring. For uterine fibroids (. Oral, once 4 tablets, 3 times a day, three menstrual cycles for a course.
Not forget that no significant bleeding when hemostatic effective, diagnostic curettage, the diagnosis is not only helpful, and also has effects on hemostasis.
Anemia and anemia should be corrected, taking vitamins, iron or blood transfusion.
Chinese medicine treatment can reduce menstrual flow, long menstrual chapter.
Where drug treatment failed, can not increase or reduce the symptoms were suspected malignancy should be surgery.


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