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Abstract: Peripheral neuropathy is IgM monoclonal immunoglobulin common complication of neuropathy, in the sense of indeterminate IgM monoclonal immunoglobulin London Manchester neuropathy or Walden's macroglobulinemia (Waldenstrom macroglobulinemia, WM) patients incidence rate of 15% to 30%. It is estimated that people over 50 years of age in the incidence rate of 30/10 million. Several forms of neuropathy and IgM monoclonal immunoglobulin-related neuropathy, including cranial nerve palsy, single or multiple neuropathy, symmetric polyneuropathy, which may reflect different pathophysiological mechanisms of their own. Number of pages: 2 Page Range :377-378 Key words: peripheral neuropathy in IgM paraprotein gamma globulin hyperlipidemia polyneuropathy people over 50 years of age pathophysiology of cranial nerve palsy macroglobulinemia subject classification: R745 [Medicine , HEALTH "Neurology and Psychi peripheral nerve and ganglion disease] R446.62 [medicine, HEALTH" Clinical Medi Diagnos Laboratory Diagnos Immunology Determination of immune substances] Related Articles: Topics related references ( 18)
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IgM paraprotein neuropathy hyperlipidemiaYou can in the "My Services" in the you add a reference to the notification list, and configure access to notices.Peripheral neuropathy is a monoclonal immunoglobulin IgM neuropathy common complication in the sense of indeterminate IgM monoclonal immunoglobulin London Manchester neuropathy or Walden's macroglobulinemia (Waldenstrom macroglobulinemia, WM) the incidence of patients 15% to 30%. It is estimated that people over 50 years of age in the incidence rate of 30/10 million. several forms of neuropathy and IgM monoclonal immunoglobulin-related neuropathy, including cranial nerve palsy, single or multiple neuropathy, symmetric polyneuropathy, which may reflect different pathophysiological mechanisms of their own. The vast majority occur in patients with slowly progressive distal symmetrical neuropathy in the majority of which 2 / 3 with IgM and some neural antigens on , including myelin associated glycoprotein, sulfatide fat, chondroitin sulfate C, cytoskeletal proteins and several ganglioside [1 ~ 3]. Although we have of these diseases between clinical and pathological correlation with the physiological considerable knowledge, but to reduce abnormal conventional IgM paraprotein or B cell clone cytotoxic or immune therapy is not satisfactory, which makes people want to find a more safe and effective immunotherapy. of: Zhou Xiaolin Zhao Yongbo Shanghai Jiaotong University Affiliated First People's Hospital, Department of Neurology, Shanghai, 200080 Title: Stroke and Nervous Diseases ISTKU English title: JOURNAL OF APOPLEXY AND NERVOUS DISEASES, the volume (of): 2005 22 (4) Key words: R745 Keywords: Machine Standard Classification: R3 R96 machine standard Key words: polyneuropathy, vice albumin monoclonal immune globulin therapy pathophysiology of myelin associated glycoprotein macroglobulinemia cytoskeleton incidence of peripheral neuropathy physiological mechanism ganglion glycoside chondroitin sulfate ester cranial nerve palsy undetermined significance common complication in patients with neuropathy clone Fund Project: DOI: References (18) Nobile-Orazio ENeuropathies associated with anti-MAG antibodies and IgM monoclonal gammopathies 1998 Nobile-Orazio E. Manfredini E . Carpo MFrequency and clinical correlates of anti-neural IgM antibodies in neuropathy associated with IgM monoclonal gammopathy 1994 Pestronk A. Choksi R. Logigian ESensory neuropathy with monoclonal IgM binding to a trisulfated heparin disaccharide 2003 Kyle RA.Rajkumar SVMonoclonal gammopathies of undetermined significance 2003 Kyle RA.Therneau TM.Rajkumar SVLong-term followup of IgM monoclonal gammopathy of undetermined significance 2003 Montoto S. Rozman M. Rosinol LMalignant transformation in IgM monoclonal gammopathy of undetermined significance 2003 Cocito D. Durelli L. Isoardo GDifferent clinical, electrophysiological and immunological features of CIDP associated with paraproteinaemia 2003 Yin X. Crawford TO.Griffin JWMyelin-associated glycoprotein is a myelin signal that modulates the caliber of myelinated axons 1998 Nobile-Orazio EMultifocal motor neuropathy (Rearticle) 2001 Noguchi M. Mori K. Yamazaki SMultifocal motor neuropathy caused by a B-cell lymphoma producing a monoclonal IgM autoantibody against peripheral nerve myelin glycolipids GM1 and GD1b 2003 Eurelings M.van den Berg LH.Wokke JHJIncrease of sural nerve T cells in progressive axonal polyneuropathy and monoclonal gammopathy 2003 Turner MR.Warren JD.Jacobs JMMicrovasculitic paraproteinaemic polyneuropathy and B-cell lymphoma 2003 Ghosh A. Littlewood T. Donaghy MCladribine in the treatment of IgM paraproteinemic polyneuropathy 2002 Comi G. Roveri L. Swan AA randomised controlled trial of intravenous immunoglobulin in IgM paraprotein associated demyelinating neuropathy 2002 Lunn MP.Nobile -Orazio EImmunotherapy for IgM antimyelin-associated glycoprotein paraprotein-associated peripheral neuropathies 2003 Rojas-Garcia R. Gallardo E. De Andres IChronic neuropathy with IgM anti-ganglioside antibodies: lack of long term response to rituximab 2003 Renaud S. Gregor M. Fuhr PRituximab in the treatment of anti-MAG associated polyneuropathy 2003 Ruzicka E. Jech R. Zarubova KVIM thalamic stimulation for tremor in a patient with IgM paraproteinaemic demyelinating neuropathy 2003
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